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Postion:Product Catalog >INCB 3284
INCB 3284
  • INCB 3284

INCB 3284 NEW

Price $51 $81 $137
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-11

Product Details

Product Name: INCB 3284 CAS No.: 887401-92-5
Purity: 99.82% Supply Ability: 10g
Release date: 2024/11/11

Product Introduction

Bioactivity

名稱INCB 3284
描述INCB 3284 is an orally available, selective and high affinity chemokine receptor 2 (CCR2) antagonist that inhibits monocyte chemotactic protein 1 from interacting with hCCR2.INCB 3284 is used in the study of hemorrhagic shock.
體外活性INCB3284 exhibited an IC50 of 3.7 nM for antagonizing the binding of monocyte chemoattractant protein-1 to hCCR2, an IC50 of 4.7 nM for antagonizing chemotactic activity, and an IC50 of 84 μM for inhibiting hERG potassium currents[1].
體內活性INCB 3284 (1 mg/kg/day, intraperitoneal injection) or C021 significantly improved the neurological outcomes in AOM-treated mice, reduced microglial activation, decreased phosphorylation of ERK1/2, and attenuated the upregulation of cytokines induced by AOM[2].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度H2O : < 0.1 mg/mL (insoluble)
DMSO : 60 mg/mL (115.26 mM), Sonication is recommended.
關鍵字INCB-3284 | INCB3284 | INCB 3284
相關產(chǎn)品Aplaviroc | AZD2098 | MLN-3897 TFA | CCR2 antagonist 5 | INCB-9471 | CCR3 antagonist 1 | BMS-817399 | PF-4136309 | C-021 | Pirfenidone | Vercirnon | CCR6 antagonist 1
相關庫經(jīng)典已知活性庫 | 細胞因子抑制劑庫 | 抑制劑庫 | 腫瘤免疫治療小分子化合物庫 | 口服活性化合物庫 | 免疫/炎癥分子化合物庫 | 已知活性化合物庫 | 含氟化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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