Product Details
| Product Name:
FDW028 |
CAS No.:
2768426-49-7 |
| Supply Ability:
10g |
Release date:
2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | FDW028 |
| 描述 | FDW028 is a selective and potent fucosyltransferase 8 (FUT8) inhibitor with anti-tumor activity that drives B7-H3 lysosomal degradation via defucosylation and CMA pathways. FUT8 can be used to study metastatic colorectal cancer (mCRC). |
| 體外活性 | METHODS: FDW028 (0.316-316μM, 72 hours) was used to treat SW480 and HCT-8 cells, and cell viability was detected with or without FUT8 knockdown.
RESULTS:FDW028 exhibited potent antitumor capabilities in terms of cell proliferation, with half-maximal inhibitory concentration (IC50) values ??of 5.95 μM and 23.78 μM in SW480 and HCT-8 cells, respectively. [1]
METHODS: SW480 and HCT-8 cells were treated with FDW028 (50 μM, 72 hours) for Transwell and wound healing assays.
RESULTS:FDW028 significantly inhibited the migration of SW480 and HCT-8 cells. [1] |
| 體內(nèi)活性 | METHODS: FDW028 (10, 20 mg/kg, intravenous injection, 4-6 weeks) was administered to athymic male SCID tumor xenograft mice to explore the effect of FDW028 on CRC growth.
RESULTS:FDW028 exerted potent antitumor activity against CRC and significantly inhibited the growth of mouse tumors. [1] |
| 存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 80 mg/mL（205.94 mM), Sonication is recommended.
|
| 關(guān)鍵字 | FDW028 |
| 相關(guān)產(chǎn)品 | Stavudine | Aceglutamide | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Valproic Acid | Curcumin | Paeonol | Naringin | Salicylic acid | Gefitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:887401-92-5
$51.00 / 5mg
-
CAS:1061353-68-1
$30.00 / 2mg
-
CAS:33237-37-5
$287.00 / 1mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States