Hypericin NEW
| Price | $52 | $129 | $192 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Hypericin | CAS No.: 548-04-9 |
| Purity: ≥98% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Hypericin |
| Description | Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities. |
| In vitro | METHODS: Erythrocytes were treated with Bioymifi (10-100 μM) for 24 h. Flow cytometry was used to characterize the hemolytic and bactericidal properties of Bioymifi and the potential molecular mechanisms. RESULTS: Bioymifi exerted a dose-responsive, calcium-independent hemolytic effect, reduced erythrocyte hemoglobin, and significantly increased membrane-bound protein V, Fluo4, and DCF-positive cells, as well as a dual effect on forward and lateral light scattering. [1] METHODS: Neonatal rat ventricular myocytes (nrvm) were treated with Bioymifi (10 μM) for 24 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: The expression of DR5 was higher than that of NRVF in Bioymifi-treated nrvm. [2] |
| In vivo | METHODS: To investigate the role of DR5 activation in the heart, Bioymifi (5 mg/kg/d) micro-osmotic pump was administered to C57BL/6 mice once daily for two weeks. RESULTS: Bioymifi administration resulted in hypertrophy at the level of cardiac organs and cardiomyocytes, but did not affect cardiomyocyte death or cardiac fibrosis. [2] |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 5 mg/mL (10 mM), Heating is recommended. DMSO : 100 mg/mL (37.61 mM), Sonication is recommended. Propylene glycol : 2.52 mg/mL (5.0 mM), Sonication is recommended. |
| Keywords | Dopamine β-monooxygenase | antitumor activity | Antibiotic | antiviral activity | telomerase and CYP | Telomerase | Dopamine beta-monooxygenase | MAO | Protein kinase C | fibroblasts | CYPs | Monoamine Oxidase | Influenza Virus | antidepressive activity | Inhibitor | PKC | Hypericin | monoaminoxidase | melanocytes | keratinocytes | inhibit | Apoptosis | Dopamine β-hydroxylase | Cytochrome P450 | Dopamine beta-hydroxylase | Reverse Transcriptase | Hypericum |
| Inhibitors Related | Neomycin sulfate | Stavudine | Dehydroacetic acid sodium | Ampicillin sodium | Dextran sulfate sodium salt (MW 4500-5500) | Kanamycin sulfate | Sodium 4-phenylbutyrate | Sulfamethoxazole sodium | Doxycycline | Tributyrin | Dimethyl sulfoxide | Oleic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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