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Postion:Product Catalog >GNE-131
GNE-131
  • GNE-131

GNE-131 NEW

Price $123 $278 $396
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: GNE-131 CAS No.: 1629063-81-5
Purity: 99.59% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameGNE-131
DescriptionGNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
In vitroGNE-131 shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 (IC50: 0.003 μM).
In vivoGNE-131 demonstrates low in vivo clearance in dogs, rats, and mice, and exhibits excellent efficacy in a transgenic mouse model of induced pain [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 120 mg/mL (271.14 mM), Sonication is recommended.
KeywordsGNE131 | Na+ channels | inhibit | Na channels | Inhibitor | GNE 131 | Sodium Channel | GNE-131
Inhibitors RelatedPhenytoin sodium | Lidocaine Hydrochloride hydrate | Lidocaine | Valproic Acid | Butamben | Lidocaine hydrochloride | L-Aspartic aicd sodium | Mebeverine hydrochloride | Amitriptyline hydrochloride | Riluzole | Benzocaine | Nefopam hydrochloride
Related Compound LibrariesPain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Sodium Channel Targeted Library | Inhibitor Library | Neuroprotective Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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