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Postion:Product Catalog >GNE-495
GNE-495
  • GNE-495

GNE-495 NEW

Price $66 $97 $148
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: GNE-495 CAS No.: 1449277-10-4
Purity: 99.22% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameGNE-495
DescriptionGNE-495 is a potent and specific inhibitor of MAP4K4 with an IC50 of 3.7 nM.
In vitroGNE-495 has efficacy in retinal angiogenesis. GNE-495 shows the best balance of MAP4K4 inhibition, permeability, microsomal stability, and cellular potency.
In vivoGNE-495 is administered at high doses (25 and 50 mg/kg) intraperitoneally to neonatal mice. This compound demonstrates superior potency and favorable pharmacokinetic (PK) profiles across all tested species, characterized by low clearance rates, moderate terminal half-lives, and acceptable levels of oral bioavailability (F=37-47%).
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 2 mg/mL (4.93 mM), Sonication is recommended.
KeywordsGNE-495 | MAPK Kinase Kinase Kinase | GNE495 | MAP4K | inhibit | GNE 495 | Inhibitor
Inhibitors RelatedSodium lauryl sulfoacetate | Nomilin | Vemurafenib | CMPD1 | SKLB-163 | MBM-55S | sodium lauroyl-α-hydroxyethyl sulfonate | NQDI-1 | Takinib | NG25 | MK2-IN-3 hydrate | Selonsertib
Related Compound LibrariesAnti-Colorectal Cancer Compound Library | Osteogenesis Compound Library | Pain-Related Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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