Gliquidone NEW
| Price | $47 | $57 | $83 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Gliquidone | CAS No.: 33342-05-1 |
| Purity: 99.93% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Gliquidone |
| Description | Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity, exhibiting greater binding affinity to SUR1 and increased potency compared to first-generation compounds. Additionally, this agent exerts peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity. |
| In vitro | Intraventricular administration of 0.06–16 μg Gliquidone to each mouse counteracts the antinociceptive effects of tramadol, morphine, and methadone. A dose of 6 μg Gliquidone intraventricularly administered to each mouse inhibits the antinociceptive responses induced by subcutaneous injections of 0.125 mg/kg clonidine and 0.30 mg/kg chlorthalidone; however, a 3 μg dose is ineffective. In male Swiss albino mice, intraventricular injections of 0.1–1.0 μg Gliquidone dose-dependently suppress the antinociceptive effects of amitriptyline and chlorphenamine. In diabetic rats, a 10 mg/kg dose of Gliquidone significantly reduces blood pressure, diminishes non-enzymatic glycation, lowers total protein levels in the lens, and notably increases glutathione levels in the lens. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 97 mg/mL (183.8 mM) Ethanol : 6 mg/mL (11.37 mM) |
| Keywords | Inhibitor | inhibit | Gliquidone |
| Inhibitors Related | Minoxidil sulfate | Glibenclamide | (±)-Naringenin | Tolbutamide | Tetraethylammonium bromide | Halothane | Butamben | Cloperastine hydrochloride | 2,2,2-Trichloroethanol | Indapamide |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Anti-Diabetic Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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