FX-11 NEW
| Price | $41 | $98 | $142 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-08 |
Product Details
| Product Name: FX-11 | CAS No.: 213971-34-7 |
| Purity: 98.95% | Supply Ability: 10g |
| Release date: 2025/06/08 |
Product Introduction
Bioactivity
| Name | FX-11 |
| Description | FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer. |
| In vitro | FX-11 (9 μM, 24-48 h) induces activation of AMP kinase and phosphorylation of acetyl-CoA carboxylase, its substrate. FX-11 disrupts glycolysis and modifies cellular energy metabolism in P493 cells. [1] FX-11 (0-100 μM, 72 h) impedes cell proliferation in BxPc-3 and MIA PaCa-2 cells. [2] |
| In vivo | FX-11 (42 μg/mouse; IP, administered daily for 10-14 days) suppresses P493 tumor growth.[1] FX-11 (0-2 mg/kg, IP, daily, for 3 weeks) notably retards tumor growth.[2] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 225.0 mg/mL (642.1 mM), Sonication is recommended. |
| Keywords | LDHA, HeLa cell | LDHA | FX-11 | FX11 | FX 11 |
| Inhibitors Related | Disulfiram | Methotrexate | Rotenone | Mycophenolate Mofetil | Ribavirin | Mycophenolic acid | 4-Diethylaminobenzaldehyde | Benzyl alcohol | Isomalt | Isoniazid | D-Mannitol | Ivosidenib |
| Related Compound Libraries | Glycometabolism Compound Library | Bioactive Compound Library | Hematonosis Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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