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Postion:Product Catalog >JC2-11
JC2-11
  • JC2-11

JC2-11 NEW

Price $38 $89 $147
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-16

Product Details

Product Name: JC2-11 CAS No.: 937820-89-8
Purity: 98.6% Supply Ability: 10g
Release date: 2024/11/16

Product Introduction

Bioactivity

名稱JC2-11
描述JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles.
體內(nèi)活性JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibited the release of caspase-1 (p20) and IL-1β from the non-canonical (NC) inflammasome in the C57BL/6 mouse model, attenuated NC inflammasome activation.[1]
存儲條件Shipping with blue ice.
溶解度DMSO : 90.0 mg/mL (297.7 mM)
關(guān)鍵字JC211 | JC2-11
相關(guān)產(chǎn)品Stavudine | Inosine pranobex | Acetylcysteine | Rotenone | Mycophenolate Mofetil | Ribavirin | L-Arginine | Tempol | Lycopene | Ethyl cinnamate | Diallyl disulfide | Isomalt
相關(guān)庫經(jīng)典已知活性庫 | 抗衰老化合物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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