Febuxostat NEW
| Price | $32 | $52 | $80 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Febuxostat | CAS No.: 144060-53-7 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Febuxostat |
| Description | Febuxostat (TEI 6720) is a xanthine oxidase inhibitor. |
| In vitro | When compared to L-isomer of sugar alone, Febuxostat (5–6 mg/kg/day) in combination with L-isomer of sugar significantly lowered uric acid, blood pressure, insulin, and triglyceride levels in rats; the combination also reduced renal vasoconstriction, glomerular pressure, and afferent arteriole constriction. Febuxostat prevented hyperuricemia, improved proteinuria, and protected renal function in rats treated with 5/6 nephrectomy (5/6 Nx) + oxonic acid (OA) + Febuxostat (Fx), and it also prevented glomerular hypertension in 5/6 Nx + vehicle (V)/OA + Febuxostat (Fx) treated rats. Post-transverse aortic constriction (TAC), Febuxostat (5 mg/kg/day, administered forcefully for 8 days) attenuated TAC-induced left ventricular (LV) hypertrophy and dysfunction. It further attenuated the increase in nitrotyrosine (indicating reduced myocardial oxidative stress), p-mTOR(Ser2488), and p-Erk(Thr202/Tyr204), without affecting total mTOR or Erk levels. Based on evaluations of nitrotyrosine, urinary 8-isoprostane, and thiobarbituric acid reactive substances, Febuxostat significantly inhibited the activity of oxonic acid and reduced oxidative stress in the kidneys of Sprague-Dawley rats with unilateral right nephrectomy and left kidney ischemia/reperfusion (I/R) injury. Febuxostat also decreased endoplasmic reticulum stress induction in these rats, as reflected by the assessment of ATF4, GRP-78, and CHOP markers. |
| In vivo | Febuxostat inhibits the activity of mixed-type purified bovine milk xanthine oxidase, with Ki and Ki' values of 0.6 nM and 3.1 nM, respectively, and is also effective against both reduced and oxidized forms of xanthine oxidase. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (158.04 mM) Ethanol : 15.8 mg/mL (50 mM) |
| Keywords | metabolic syndrome | Inhibitor | p-mTOR | Hyperuricemia | Febuxostat | TEI6720 | gout | TMX-67 | TEI-6720 | TMX67 | inhibit | p-Erk | Xanthine Oxidase |
| Inhibitors Related | Allopurinol | Acetylcysteine | Tempol | Inosine | Phytic acid dodecasodium salt hydrate | Lycopene | Ethyl cinnamate | Rifamycin S | 4-Hydroxyacetophenone |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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