Gout is a disease based on hyperuricemia that caused by normal purine metabolism and uric acid excretion disorder. The main symptoms of this metabolic disease are needle crystals of sodium urate deposition in the organization, the recurrence of typical acute arthritis and kidney lesion. It is generally considered to be a disease mainly happened on rich people, because the gravy, seafood and other foods they eat contain more purine, easily lead to ventilation, while the food of purine in the past attract little attention.
Anti-gout drugs are now divided into two categories.
(1) anti-inflammatory analgesic
In addition to indomethacin (indomethacin) and phenylbutazone, the colchicine is also a special anti-gout drug.
Colchicine exists in the seeds or bulbs of the Liliaceae plant, Colchicum. Egypt, Greece use colchicine since ancient times. The mechanism of action is not clear. It is believed that may be directly prevent leukocyte phagocytosis of uric acid, or act on the white blood cell lysosome and stabilize it, cut off uric acid crystallization and inflammation between the cycle.
(2) xanthine oxidase inhibitors
Allopurinol is synthesized during the study of anticancer drugs. RWRundles et al. found it will be a substrate for xanthine oxidase in a test tube, and act as an inhibitor, inhibiting the formation of uric acid by three-step oxidation of purine, and have an inhibitory effect on the reaction of each step. In 1963, J. B. Wyngaarden applied allopurinol clinical trials in London, and reported it can be used to correct hyperuricemia.
(3) uric acid excretion agent
① thiadiazolone (benzene sulfonazolone) Ciba-Geigy's trade name is Anturane. This product has inhibition of renal tubular reabsorption of uric acid, and this is an anti-gout drug found in the study of the elimination of the side effects of phenylbutazone pyrazolone.
② probenecid (carboxy benzene sulfonamides) , the goods also inhibit renal tubular reabsorption of uric acid.
③ benzbromarone (bromophenol ketone)