Dimethyl fumarate NEW
| Price | $45 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: Dimethyl fumarate | CAS No.: 624-49-7 |
| Purity: 99.88% | Supply Ability: 10g |
| Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | Dimethyl fumarate |
| Description | Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis. |
| In vitro | METHODS: Primary cortical cultures or hippocampal HT22 cells were treated with Dimethyl fumarate (10 μM) and glutamate for 24 h. Cell viability was measured by Cell Titer Blue (CTB) assay. RESULTS: Pre-incubation with 10 μM MMF Dimethyl fumarate for 24 h protected primary cortex cultures and hippocampal HT22 cells from oxidized glutamate toxicity. [1] METHODS: Tumor cells CT26 were treated with Dimethyl fumarate (100 μM) for 3-24 h. LDH release was detected by LDH cytotoxicity assay kit. RESULTS: Dimethyl fumarate time-dependently increased LDH release, which reflected necrotic cell death. [2] |
| In vivo | METHODS: To study the effects on Friedreich's ataxia (FA), Dimethyl fumarate (110 mg/kg) was administered orally to a FXNKD mouse model of FA once daily for 18 weeks. RESULTS: Dimethyl fumarate rescued these enzyme activities in the brain of the FXNKD mouse model and rescued frataxin and cytochrome oxidase expression in the brain, cerebellum, and quadriceps muscle. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 15 mg/mL (104.07 mM), Sonication is recommended. 10% DMSO+90% Saline : 1.5 mg/mL (10.41 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Ethanol : 7.2 mg/mL (49.95 mM), Sonication is recommended. 5% DMSO+95% Saline : 0.29 mg/mL (2.01 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. |
| Keywords | sclerosis | ROS | ReactiveOxygenSpecies | Reactive Oxygen Species | neuroprotective | KEAP1-Nrf2 | Keap1-Nrf2 | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | EndogenousMetabolite | Endogenous Metabolite | Dimethyl Fumarate | Dimethyl fumarate | Dimethyl | brain-penetrant | Autophagy | Antioxidant | anti-inflammatory |
| Inhibitors Related | Sucrose | Emtricitabine | Hydroxychloroquine | Daidzein | Lamivudine | Guanidine hydrochloride | Ferulic Acid | Formamide | Paeonol | Glycerol | Thymidine | 3-Indoleacetic acid |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Natural Product Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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