Dimethyl fumarate NEW
| Price | $45 | $45 |
| Package | 500mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Dimethyl fumarate | CAS No.: 624-49-7 |
| Purity: 90.51% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Dimethyl fumarate |
| Description | Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis. |
| In vitro | METHODS: Primary cortical cultures or hippocampal HT22 cells were treated with Dimethyl fumarate (10 μM) and glutamate for 24 h. Cell viability was measured by Cell Titer Blue (CTB) assay. RESULTS: Pre-incubation with 10 μM MMF Dimethyl fumarate for 24 h protected primary cortex cultures and hippocampal HT22 cells from oxidized glutamate toxicity. [1] METHODS: Tumor cells CT26 were treated with Dimethyl fumarate (100 μM) for 3-24 h. LDH release was detected by LDH cytotoxicity assay kit. RESULTS: Dimethyl fumarate time-dependently increased LDH release, which reflected necrotic cell death. [2] |
| In vivo | METHODS: To study the effects on Friedreich's ataxia (FA), Dimethyl fumarate (110 mg/kg) was administered orally to a FXNKD mouse model of FA once daily for 18 weeks. RESULTS: Dimethyl fumarate rescued these enzyme activities in the brain of the FXNKD mouse model and rescued frataxin and cytochrome oxidase expression in the brain, cerebellum, and quadriceps muscle. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 15 mg/mL (104.07 mM), Sonication is recommended. Ethanol : 7.2 mg/mL (50 mM) |
| Keywords | Antioxidant | Dimethyl fumarate | Autophagy | neuroprotective | Dimethyl | Inhibitor | Keap1-Nrf2 | inhibit | Endogenous Metabolite | anti-inflammatory | Reactive Oxygen Species | Dimethyl Fumarate | brain-penetrant | ROS | Human immunodeficiency virus | sclerosis | HIV |
| Related Compound Libraries | Bioactive Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Natural Product Library | Natural Product Library for HTS | FDA-Approved Drug Library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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