DDP-38003 trihydrochloride NEW
Price | $1570 |
Package | 100mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: DDP-38003 trihydrochloride | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | DDP-38003 trihydrochloride |
Description | DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM. |
In vitro | DDP-38003 inhibits KDM1A with an IC50 of 84 nM. It is more effective in reducing colony-forming ability and inducing differentiation of THP-1 cells compared to the 1R, 2S analogue [1]. |
In vivo | DDP-38003 demonstrates effectiveness in vivo upon oral administration, leading to a 62% increase in survival rates in mouse leukemia models via KDM1A inhibition. It has a half-life of 8 hours. A notable dose-dependent enhancement in survival rates of mice treated with DDP-38003 is observed, with survival rates escalating by 35% and 62% at doses of 11.25 and 22.50 mg/kg, respectively, showcasing its potential as a cancer therapeutic [1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 100 mg/mL (217.47 mM), Sonication is recommended. |
Keywords | DDP 38003 Trihydrochloride | DDP 38003 trihydrochloride | DDP-38003 Trihydrochloride | DDP38003 | DDP38003 Trihydrochloride | DDP 38003 | DDP38003 trihydrochloride | DDP-38003 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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airuikechemical co., ltd.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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