DDP-38003 dihydrochloride NEW
| Price | $73 | $140 | $240 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: DDP-38003 dihydrochloride | CAS No.: 1831167-98-6 |
| Purity: 99.5% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | DDP-38003 dihydrochloride |
| Description | DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM). |
| In vitro | DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue. DDP-38003 inhibits KDM1A (IC50: 84 nM) [1]. |
| In vivo | DDP-38003, an oral anticancer candidate, possesses a half-life of 8 hours and demonstrates in vivo efficacy, resulting in a 62% survival increase in mouse leukemia models through KDM1A inhibition. The treatment's efficacy is dose-dependent, with survival rates augmenting by 35% and 62% at doses of 11.25 mg/kg and 22.50 mg/kg, respectively[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 10 mg/mL (23.62 mM), Sonication is recommended. |
| Keywords | DDP-38003 | DDP 38003 Dihydrochloride | DDP-38003 Dihydrochloride | DDP 38003 dihydrochloride | DDP 38003 | DDP38003 dihydrochloride | DDP38003 | DDP38003 Dihydrochloride |
| Inhibitors Related | LSD1-IN-24 | Tranylcypromine hemisulfate | GSK-LSD1 dihydrochloride | GSK-J4 | FY-21 | Daminozide | Zavondemstat | AS8351 | Procaine hydrochloride | JIB-04 |
| Related Compound Libraries | Histone Modification Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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