CDKI-73 NEW
Price | $146 | $198 | $308 |
Package | 1mg | 2mg | 5mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-18 |
Product Details
Product Name: CDKI-73 | CAS No.: 1421693-22-2 |
Purity: 98.11% | Supply Ability: 10g |
Release date: 2024/11/18 |
Product Introduction
Bioactivity
名稱 | CDKI-73 |
描述 | CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin. |
體外活性 | CDKI-73, one of the most potent CDK9 inhibitors, against a panel of AML cell lines and samples derived from 97 patients.?CDKI-73 induced cancer cells undergoing apoptosis through transcriptional downregulation of anti-apoptotic proteins Bcl-2, Mcl-1 and XIAP by majorly targeting CDK9[3]. |
體內(nèi)活性 | CDKI-73 exhibited a favorable pharmacokinetic profile with oral bioavailability of F = 56% following a single intravenous bolus dose at 2 mg/kg and an oral dose at 10 mg/kg in mice [1]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 52 mg/mL (131.83 mM) |
關鍵字 | toxicity | myeloid | LS-007 | LS007 | LS 007 | low | leukemia | Inhibitor | inhibit | endosome | Cyclin dependent kinase | CLL | CDKI-73 | CDKI73 | CDKI 73 | CDK | Apoptosis | AML | Acute |
相關產(chǎn)品 | Stavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Sorafenib | Tributyrin | Salicylic acid | Oleic acid |
相關庫 | 細胞凋亡化合物庫 | 抗胰腺癌化合物庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 抑制劑庫 | NO PAINS 化合物庫 | 口服活性化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 細胞周期化合物庫 | 含氟化合物庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$1520.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-23 | |
$0.00/1kg |
VIP2Y
|
Chongqing Zhihe Biopharmaceutical Co., Ltd.
|
2023-12-18 | |
$6.00/1KG |
VIP1Y
|
Hebei Longbang Technology Co., Ltd
|
2024-05-22 | |
$146.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-18 |
- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY