AU-15330 NEW
| Price | $139 | $347 | $538 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: AU-15330 | CAS No.: 2380274-50-8 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | AU-15330 |
| Description | AU-15330 is a proteolytic targeting chimera (PROTAC) that simultaneously targets SMARCA4, SMARCA2, and PBRM1 for degradation and exhibits cytotoxicity in H3.3K27M cells but not in H3 wild-type cells. [2] |
| In vitro | METHODS: PCa cells (LNCaP, VCaP, 22RV1, and LAPC4) were treated with different concentrations of AU-15330 (0.1, 1 μM). RESULTS AU-15330 attenuated the growth of these cells and induced apoptotic cell death, while having no antiproliferative effect on benign or non-neoplastic prostate cells. [1] |
| In vivo | METHODS: AU-15330 (60 mg kg, i.v.) was administered to mice bearing VCaP and C4-2B castration-resistant tumor models, 3 days per week. RESULTS AU-15330 inhibited tumor growth in mice bearing VCaP and C4-2B castration-resistant tumor models without significant toxicity. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 126.0 mg/mL (166.7 mM), Sonication is recommended. |
| Keywords | AU-15330 | AU15330 | AU 15330 |
| Inhibitors Related | ABBV-744 | CeMMEC1 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | (+)-JQ-1 | ARV-471 | Curcumin | dBET6 | Naphthol AS-E | Bisdemethoxycurcumin |
| Related Compound Libraries | Histone Modification Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1520.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
| $293.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-20 | |
| $1.00/1KG |
VIP6Y
|
Hebei Weibang Biotechnology Co., Ltd
|
2024-11-01 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY