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Postion:Product Catalog >Natural Products>Terpenes>7-Epi 10-desacetyl paclitaxel
7-Epi 10-desacetyl paclitaxel
  • 7-Epi 10-desacetyl paclitaxel

7-Epi 10-desacetyl paclitaxel NEW

Price $110
Package 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: 7-Epi 10-desacetyl paclitaxel CAS No.: 78454-17-8
Purity: 98.05% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name7-Epi 10-desacetyl paclitaxel
Description7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
Cell ResearchThe endophytic fungus was identified by traditional and molecular taxonomical characterization and the fungal 7-Epi-10-deacetyltaxol(EDT) was purified using column chromatography and confirmed by various spectroscopic and chromatographic comparisons with authentic paclitaxel.?Studied the in vitro effects of EDT on HepG2 cells for parameters such as cell cycle distribution, DNA fragmentation, reactive oxygen species (ROS) generation and nuclear morphology.?Further, western blot analysis was used to evaluate Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), p38-mitogen activated protein kinase (MAPK) and poly [ADP-ribose] polymerase (PARP) expression[1].
In vitro7-Epi-10-deacetyltaxol(EDT) exhibited significant in vitro cytotoxicity in HepG2 cells.Nuclear condensation and DNA fragmentation were observed in cells treated with fungal EDT.?Besides, the fungal EDT arrested HepG2 cells at G2/M phase of cell cycle.?Furthermore, fungal EDT induced apoptosis in HepG2 cells in a dose-dependent manner associated with ROS generation and increased Bax/Bcl-2 ratio, p38 MAPKs and PARP cleavage[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 8.11 mg/mL (9.99 mM)
Keywords7Epi 10desacetyl paclitaxel | 7 Epi 10 desacetyl paclitaxel | 7-Epi 10-desacetyl paclitaxel | Inhibitor | inhibit
Inhibitors RelatedMethotrexate | Mertansine | Doxorubicin hydrochloride | Daunorubicin hydrochloride | Exatecan | Camptothecin | Methotrexate disodium | Dexamethasone | Fluticasone (propionate) | Paclitaxel | Budesonide | Exatecan Mesylate
Related Compound LibrariesTerpene Natural Product Library | Bioactive Compound Library | Natural Product Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Tibetan medicine Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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