10-Deacetyl-7-xylosyl paclitaxel NEW
| Price | $50 |
| Package | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 10-Deacetyl-7-xylosyl paclitaxel | CAS No.: 90332-63-1 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 10-Deacetyl-7-xylosyl paclitaxel |
| Description | 10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer. |
| In vitro | 10-Deacetyl-7-xylosyl paclitaxel induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9[1]. |
| In vivo | 10-Deacetyl-7-xylosyl paclitaxel is an active compound used in traditional Chinese medicine to treat cancer.10-Deacetyl-7-xylosyl paclitaxel through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 10-Deacetyl-7-xylosyl paclitaxel transport (16.3±6.3×10 (-6)cm/s; n=3) suggests that the drug may still be effectively absorbed in the intestinal tract[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 25 mg/mL (26.48 mM) |
| Keywords | inhibit | 10-Deacetyl-7-xylosyl paclitaxel | 10Deacetyl7xylosyl paclitaxel | Microtubule/Tubulin | ADC Payload | 10 Deacetyl 7 xylosyl paclitaxel | ADC Cytotoxin | Inhibitor |
| Inhibitors Related | Methotrexate | Flubendazole | Mebendazole | N-Phenylbenzylamine | Camptothecin | 4-Isopropoxybenzoic acid | Oxfendazole | Dexamethasone | Methylene Blue trihydrate | Griseofulvin | Paclitaxel | 4'-Demethylepipodophyllotoxin |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Microtubule-Targeted Compound Library | Natural Product Library | Saccharide and Glycoside Natural Product Library | Natural Product Library for HTS | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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