2',5'-Dideoxyadenosine NEW
| Price | $33 | $76 | $122 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 2',5'-Dideoxyadenosine | CAS No.: 6698-26-6 |
| Purity: 99.55% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 2',5'-Dideoxyadenosine |
| Description | 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor, binding to the P-site with an IC50 of 3 μM. |
| Cell Research | Primary hippocampal neurons. Concentration: 10 μM. Incubation Time: 30 min [3] |
| Animal Research | Male Wistar rats (3-4 months old).Dosage: 0.1 mg/kg.Administration: i.p.; 15 min pre-treated [3] |
| In vitro | 2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3]. |
| In vivo | 2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) completely inhibits the natriuretic, diuretic, and K+ and Cl- sparing effects of Fr-EtOAc in rats [4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 2.35 mg/mL (10 mM) |
| Keywords | P-site | Adrenergic Receptor | 2',5'Dideoxyadenosine | Adenylyl cyclase | cyclase | Beta Receptor | analog | heart | adenylyl | antiadrenergic | Inhibitor | Adenylate Cyclase | 2',5'-Dideoxyadenosine | inhibit | nucleoside | 2',5' Dideoxyadenosine |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Arecoline hydrobromide | Forskolin | CLOZAPINE N-OXIDE | Pilocarpine nitrate | Ribavirin | Octopamine hydrochloride | Adenine | Choline chloride | Propoxur | Trazodone hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Nucleotide Compound Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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