2',5'-Dideoxyadenosine NEW
| Price | $33 | $76 | $122 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 2',5'-Dideoxyadenosine | CAS No.: 6698-26-6 |
| Purity: 99.55% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 2',5'-Dideoxyadenosine |
| Description | 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor, binding to the P-site with an IC50 of 3 μM. |
| Cell Research | Primary hippocampal neurons. Concentration: 10 μM. Incubation Time: 30 min [3] |
| Animal Research | Male Wistar rats (3-4 months old).Dosage: 0.1 mg/kg.Administration: i.p.; 15 min pre-treated [3] |
| In vitro | 2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3]. |
| In vivo | 2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) completely inhibits the natriuretic, diuretic, and K+ and Cl- sparing effects of Fr-EtOAc in rats [4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 2.35 mg/mL (10 mM) |
| Keywords | P-site | Adrenergic Receptor | 2',5'Dideoxyadenosine | Adenylyl cyclase | cyclase | Beta Receptor | analog | heart | adenylyl | antiadrenergic | Inhibitor | Adenylate Cyclase | 2',5'-Dideoxyadenosine | inhibit | nucleoside | 2',5' Dideoxyadenosine |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Arecoline hydrobromide | Forskolin | CLOZAPINE N-OXIDE | Pilocarpine nitrate | Ribavirin | Octopamine hydrochloride | Adenine | Choline chloride | Propoxur | Trazodone hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Nucleotide Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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