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Orlistat
Orlistat, a high-efficiency weight loss drug Orlistat

Product name: Orlistat

Chinese name: Orlistat

Chinese synonyms: orlistat; orlistat (lipase inhibitor); orlistat; orlistat; Xenical; orlistat; 3-hexyl-4-[(2S)- 2-Hydroxytridecyl]-2-oxetanone N-formyl-L-leucine ester; orlistat raw material

English name: Orlistat

Molecular formula: C29H53NO5

Molecular weight: 495.73

Appearance: white crystalline powder

Density: 0.976 G/CM3

Melting point: <50℃

Boiling point: 615.9 oC at 760 mmHg

Refractive index: 1.469

Flash point: 326.3℃

Water: DMSO:mg/mL in water

Solubility: mg/mL in water

Vapor pressure: 4.23E-15mmHg at 25°C

Color/Table: White

Spectral characteristics: Specific optical rotation at 20°C: -32.0° (C = 1 in chloroform)

Ethanol negative rotation at 529 nm

Storage conditions: 2-8°C

CAS Number: 96829-58-2

Chemical properties: Orlistat is a long-acting and potent specific gastrointestinal lipase inhibitor. It is white or off-white powder at room temperature. It is insoluble in water, soluble in chloroform, and easily soluble in ethanol. It passes through the stomach It forms a covalent bond with the active serine site of gastric lipase and pancreatic lipase in the lumen of the small intestine to inactivate the enzyme. The molecule of orlistat is a diastereomer containing four chiral centers. At a wavelength of 529nm, its ethanol solution has negative optical rotation.

Orlistat uses:
1. Orlistat's weight loss effect
Orlistat is a potent, specific and long-acting gastrointestinal lipase inhibitor. In pharmacological research, orlistat, as a pentoxonidase, can act in the stomach and small intestine lumen, covalently bond with the serine residues in the active site of lipase in the stomach and pancreas, and strongly inhibit the pancreas. The activity of carboxyl esterase and phospholipase A2 in the gastrointestinal tract slows down the hydrolysis of food fats in the gastrointestinal tract into amino acids and monoacylglycerols, thereby blocking the hydrolysis and absorption of one-third of the fat in the diet and reducing body fat Store and lose weight. Orlistat can be used clinically in obesity and hyperlipidemia. Under normal circumstances, 120mg can be taken orally once, three times a day, taken during or 1 hour after a meal. Weight can begin to drop after 2 weeks of taking the medicine. It can be taken continuously for 6-12 months, if the dose is increased to more than 400mg per day, its effect will no longer be enhanced.

2. Orlistat improves cardiovascular risk factors
Orlistat can significantly reduce the ratio of triglycerides, apolipoprotein B and LDL/HDL cholesterol; reduce the influence of obesity-related risk factors such as insulin resistance and blood sugar. The influence of orlistat on several blood lipid indexes is not directly related to the magnitude of weight loss. This unique pharmacological effect of lowering blood lipids may be related to the reduction of the absorption of fat in the diet; the possible mechanism for the improvement of blood sugar is to reduce the abdominal cavity Internal fat improves the metabolism of blood lipids, increases the sensitivity of insulin, and improves the efficacy of insulin. Orlistat can significantly reduce fasting insulin levels.

Orlistat production process: At present, most domestic manufacturers use fully synthetic technology to obtain orlistat products. Although the cost of raw materials is reduced, the purity and biological potency are reduced. The Orlistat products we produce are derived from a combination of fermentation products and chemical synthesis, with high purity and remarkable effects.

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