Orlistat NEW
| Price | $52 | $133 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-19 |
Product Details
| Product Name: Orlistat | CAS No.: 96829-58-2 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2025/06/19 |
Product Introduction
Bioactivity
| Name | Orlistat |
| Description | Orlistat (Tetrahydrolipstatin) is a lipase inhibitor and a fatty acid synthase (FASN) inhibitor. Orlistat has been shown to promote weight loss. |
| In vitro | METHODS: Prostate cancer cells PC3, DU145 and LNCaP were treated with Orlistat (10-300 μM) for 24 h and cell proliferation was detected by MTT assay. RESULTS: Increasing concentrations of Orlistat resulted in a dose-dependent decrease in cell viability of the three PCa cell lines tested. [1] METHODS: Breast cancer cells SK-Br3 were treated with Orlistat (40 μM) for 6-72 h. Cell cycle was measured by Flow cytometry. RESULTS: The time-dependent response of SK-Br3 breast cancer cells to Orlistat was characterized by the absence of G2-M populations and the accumulation of cells in the S phase of the cell cycle. Importantly, Orlistat exposure significantly promoted apoptosis, as evidenced by the time-dependent accumulation of sub-G1 populations with <2N DNA and representing dead cells. [2] |
| In vivo | METHODS: To detect anti-tumor activity in vivo, Orlistat (240 mg/kg, 33% ethanol and 66% PEG 400) was injected intraperitoneally into athymic nude mice bearing PC-3 xenografts once daily for three weeks. RESULTS: Orlistat prevented PC-3 tumor growth. In five separate experiments, tumor growth was blocked by 63%, 62%, 46%, 41%, and 16%. [3] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (90.78 mM), Sonication is recommended. Ethanol : 49.6 mg/mL (100.05 mM), Sonication is recommended. 33% Ethanol + 67% PEG 400/PEG 300 : 10 mg/mL (20.17 mM), Solution. |
| Keywords | triacylglycerol lipase | synthase | pancreatic | Orlistat | oncogene | metabolic | lipases | Inhibitor | inhibit | gastric | FattyAcidSynthase | Fatty Acid Synthase (FASN) | Fatty Acid Synthase | fatty | FASN | FAS | atherosclerotic | Apoptosis | Anti-obesity | acid |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
| Related Compound Libraries | Highly Selective Inhibitor Library | Bioactive Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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