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Postion:Product Catalog >Biochemical Engineering>Inhibitors>GPCR & G Protein>Endothelin Receptor Antagonists>Ambrisentan
Ambrisentan
  • Ambrisentan

Ambrisentan

Price $254
Package 10g/Bag
Min. Order: 10KG
Supply Ability: 10kg
Update Time: 2024-11-14

Product Details

Product Name: Ambrisentan CAS No.: 177036-94-1
EC-No.: 658-059-9 Min. Order: 10KG
Purity: 99% Supply Ability: 10kg
Release date: 2024/11/14

CAS: 177036-94-1

MF: C22H22N2O4

MW: 378.42

EINECS: 658-059-9

Melting point >150°C (dec.)

Boiling point 551.1±60.0 °C(Predicted)

density 1.228±0.06 g/cm3(Predicted)

storage temp. -20°C Freezer


Ambrisentan is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors.



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  • Since: 2008-05-08
  • Address: No.10,the 4th road of High-tech zone, Baoji City, Shaan’xi province, Mainland China
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