2'-脫氧-2-氟胞苷
| 中文名稱 | 2'-脫氧-2-氟胞苷 |
|---|---|
| 中文同義詞 | 2'-氟-2'-脫氧胞苷(2'-F-2'-DC);2'-脫氧-2'-氟胞苷;2'-脫氧-2-氟胞苷;2\'-脫氧-2\'-氟胞啶;2'-氟-2'-脫氧胞苷;2'-氟脫氧胞苷;2'-脫氧-2'-氟胞苷水合物;2'-氟-2'-脫氧胞苷, >98.0%(T) |
| 英文名稱 | 2'-Deoxy-2'-fluorocytidine |
| 英文同義詞 | 4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;4-AMINO-1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDIN-2-ONE;2'-FC;2'-FdC;1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine;1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine;RO-8013;2'-DEOXY-2'-FLUOROCYTIDINE(2'-FLUORO-2'- DEOXYCYTIDINE, 2'-FC) |
| CAS號(hào) | 10212-20-1 |
| 分子式 | C9H12FN3O4 |
| 分子量 | 245.21 |
| EINECS號(hào) | 1806241-263-5 |
| 相關(guān)類別 | 雜環(huán)化合物;嘧啶核苷酸;核酸;生化試劑;阿糖;植物激素及核酸類;核苷，核苷酸，寡核苷酸;中間體;生化試劑-植物激素及核酸類;醫(yī)藥原料;2‘-脫氧氟代修飾類;Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents |
| Mol文件 | 10212-20-1.mol |
| 結(jié)構(gòu)式 |  |
2'-脫氧-2-氟胞苷 性質(zhì)
| 熔點(diǎn) | 167 °C |
|---|---|
| 沸點(diǎn) | 500.1±60.0 °C(Predicted) |
| 密度 | 1.82±0.1 g/cm3(Predicted) |
| 折射率 | 80 ° (C=1, MeOH) |
| 儲(chǔ)存條件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | 溶于DMSO、甲醇。 |
| 酸度系數(shù)(pKa) | 12.84±0.70(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 白色至類白色 |
| 水溶解性 | Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C) |
| InChI | InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1 |
| InChIKey | NVZFZMCNALTPBY-XVFCMESISA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O |
| CAS 數(shù)據(jù)庫(kù) | 10212-20-1(CAS DataBase Reference) |
2'-Deoxy-2'-fluorocytidine 是一種核苷類似物，是剛果出血熱病毒 (CCHFV) 復(fù)制的有效抑制劑。2'-Deoxy-2'-fluorocytidine 可與 T705 協(xié)同作用，增強(qiáng)兩種化合物對(duì) CCHFV 復(fù)制的抗病毒效力。
2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC 50 ) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC 50 ) of >50.0 μM in Huh7 cells.
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-W012009 | 2'-脫氧-2-氟胞苷 2'-Deoxy-2'-fluorocytidine | 10212-20-1 | 100mg | 200元 |
| 2025/05/22 | HY-W012009 | 2'-脫氧-2-氟胞苷 2'-Deoxy-2'-fluorocytidine | 10212-20-1 | 10mM * 1mLin Water | 220元 |