普啉索旦
中文名稱 | 普啉索旦 |
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中文同義詞 | 普啉索旦;化合物 T12720;化合物 PRINOXODAN |
英文名稱 | Prinoxodan |
英文同義詞 | Prinoxodan;RGW2938;Prinoxodan (RGW2938);2(1H)-Quinazolinone, 3,4-dihydro-3-methyl-6-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)- |
CAS號 | 111786-07-3 |
分子式 | C13H14N4O2 |
分子量 | 258.28 |
EINECS號 | |
相關(guān)類別 | |
Mol文件 | 111786-07-3.mol |
結(jié)構(gòu)式 |
普啉索旦 性質(zhì)
熔點 | >250 °C |
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密度 | 1.47±0.1 g/cm3(Predicted) |
儲存條件 | Store at -20°C |
溶解度 | 溶于二甲基亞砜 |
形態(tài) | 固體 |
酸度系數(shù)(pKa) | 13.58±0.40(Predicted) |
顏色 | 白色至黃色 |
Phosphodiesterase
Prinoxodan (RG W-2938) is an orally effective positive inotropic/vasodilator agent. Prinoxodan is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vitro in isolated guinea pig hearts; in the latter, Prinoxodan 5 nmol-5 μmol increases contractility in a dose-related fashion.
Prinoxodan (RG W-2938) is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vivo in anesthetized and conscious dogs. Prinoxodan 30-300 μg/kg administered intravenously (i.v.) to anesthetized dogs increases contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. Heart rate (HR) is only slightly increased, and aortic flow is not appreciably altered. A single oral dose of Prinoxodan 0.3 mg/kg administered to conscious chronically instrumented dogs produces a marked and sustained increase in contractility 15-240 min after treatment while only slightly increasing HR. The effects of Prinoxodan 30-300 μg/kg, i.v. are studied in a mecamylamine-propranolol-induced model of heart failure. Prinoxodan effectively reverses the drug-induced heart failure by increasing myocardial contractility and decreasing arterial pressure while only slightly affecting HR.
安全信息
更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
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2024/11/08 | HY-U00208 | 普啉索旦 Prinoxodan | 111786-07-3 | 1mg | 2500元 |
2024/08/19 | HY-U00208 | Prinoxodan | 5 mg | 6200元 |