SHA 68
| 中文名稱 | SHA 68 |
|---|---|
| 中文同義詞 | N-(4-氟芐基)-3-氧代-1,1-二苯基四氫-1H-惡唑并[3,4-A]吡嗪-7(3H)-羧酰胺;化合物SHA 68;SHA 68,神經(jīng)肽S受體拮抗劑;N-(4-氟芐基)-3-氧代-1,1-二苯基四氫-3H-惡唑并[3,4-A]吡嗪-7(1H)-甲酰胺 |
| 英文名稱 | SHA 68 |
| 英文同義詞 | SHA 68;N-(4-fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide;N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-;N-(4-Fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;N-[(4-fluorophenyl)methyl]-3-oxo-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]pyrazine-7-carboxamide |
| CAS號 | 847553-89-3 |
| 分子式 | C26H24FN3O3 |
| 分子量 | 445.49 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 847553-89-3.mol |
| 結(jié)構(gòu)式 |  |
SHA 68 性質(zhì)
| 沸點(diǎn) | 727.8±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.35±0.1 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | DMF：16 mg/ml； DMSO：14 mg/ml；乙醇：20 mg/ml；乙醇:PBS (pH 7.2)(1:2): 0.33 mg/ml |
| 形態(tài) | 結(jié)晶固體 |
| 酸度系數(shù)(pKa) | 13.32±0.40(Predicted) |
| 顏色 | 白色至米白色 |
SHA 68 是一種有效的選擇性非肽神經(jīng)肽 S 受體 (NPSR) 拮抗劑，對 NPSR Asn107 和 NPSR Ile107 的 IC50 分別為 22.0 和 23.8 nM。SHA 68 具有有限的血腦屏障 (BBB) 滲透能力和用于神經(jīng)痛的活性。
IC50: 22 nM (Asn 107 ) and 23.8 nM (Ile 107 )
SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing.
SHA 68 (i.v.; 1 mg/kg) has a T
1/2
of 0.74 hours, a CL of 4.29 mL/min/kg, and a V
ss
of 2.53 L/kg.
SHA 68 (i.p.; 2.5 mg/kg) has a T
1/2
of 0.43 hours, a CL of 4.56 mL/min/kg.
| Animal Model: | Male C57BL/6 mice age 8-12 weeks |
| Dosage: | 5 and 50 mg/kg |
| Administration: | i.p. |
| Result: | Reduced NPS-induced horizontal activity and vertical rearing and climbing. |
| Animal Model: | Male C57BL/6 mice age 8-12 weeks |
| Dosage: | 1 mg/kg (Pharmacokinetic Analysis) |
| Administration: | i.p. |
| Result: | Had a T 1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a V ss of 2.53 L/kg. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-108625 | SHA 68 | 847553-89-3 | 5 mg | 825元 |
| 2025/02/08 | HY-108625 | SHA 68 SHA 68 | 847553-89-3 | 10mM * 1mLin DMSO | 907元 |