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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Suppliers list
Company Name: Nanjing Shizhou Biotechnology Co., Ltd
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Products Intro: Product Name:9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
CAS:981-34-0
Purity:98% Package:1kg/
Company Name: Nantong Guangyuan Chemicl Co,Ltd
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Products Intro: Product Name:16-beta Methyl Epoxide
CAS:981-34-0
Purity:99% Package:1kg;10.00;USD
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
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Products Intro: Product Name:DB11(16β-Methyl Epoxide)
CAS:981-34-0
Purity:99% Package:25KG;5KG;1KG
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070
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Products Intro: CAS:981-34-0
Purity:98% Package:g-Kg Remarks:White or almost white crystalline powder
Company Name: Hubei XinRunde Chemical Co., Ltd.
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Products Intro: Product Name:9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
CAS:981-34-0
Purity:99.9% Package:1KG;100USD

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione manufacturers

  • 11beta-Epoxy-17alpha
  • 11beta-Epoxy-17alpha pictures
  • $0.10 / 1kg
  • 2023-07-31
  • CAS:981-34-0
  • Min. Order: 10kg
  • Purity: 99%
  • Supply Ability: 5000kg
  • DB11
  • DB11 pictures
  • $1.50 / 1g
  • 2023-07-27
  • CAS:981-34-0
  • Min. Order: 1g
  • Purity: 99.0% Min
  • Supply Ability: 100 Tons
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Basic information
Product Name:9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Synonyms:16-BETA METHYL EPOXIDE;9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione;(9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione;9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione;Einecs 213-563-4;Betamethasone 9,11-Epoxide;(9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione;(9β,11β,16β)-
CAS:981-34-0
MF:C22H28O5
MW:372.45
EINECS:213-563-4
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids;981-34-0
Mol File:981-34-0.mol
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Structure
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Chemical Properties
Melting point 210-220 ºC
Boiling point 564.9±50.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)
vapor pressure 0-357.304Pa at 25℃
storage temp. Refrigerator
solubility Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)
form Solid
pka12.56±0.70(Predicted)
color White to Light Beige
InChIKeyGBDXNHBVYAMODG-OBDZOPJXNA-N
SMILESC[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|
Safety Information
MSDS Information
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Usage And Synthesis
Description9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.
Chemical PropertiesOff-White Solid
Uses9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.
PreparationAdd sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Preparation Products And Raw materials
Tag:9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione(981-34-0) Related Product Information
16-beta Methyl Epoxide ETHYLENE OXIDE Betamethasone 17-valerate Propylene glycol Estradiol Betamethasone 21-phosphate disodium 4,4'-Diphenylmethane diisocyanate Phenolic epoxy resin Basic Violet 1 Polyethylene Glycol Betamethasone 21-acetate Methylparaben Methylene Blue Kresoxim-methyl Acetonitrile BETAMETHASONE DIPROPIONATE MM(CRM STANDARD) Betamethasone Methyl acrylate