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| | 1-Methylpiperidine-4-carboxylic acid hydrochloride Basic information |
| Product Name: | 1-Methylpiperidine-4-carboxylic acid hydrochloride | | Synonyms: | 4-CARBOXY-1-METHYL-PIPERIDINE HCL;BIO-FARMA BF002150;1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID HCL;1-METHYLPIPERIDINO-4-CARBOXYLIC ACID HYDROCHLORIDE;1-METHYL-4-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE;TIMTEC-BB SBB003751;RARECHEM AH CK 0139;4-Carboxy-1-methylpiperidine hydrochloride, 1-Methylisonipecotic acid hydrochloride | | CAS: | 71985-80-3 | | MF: | C7H14ClNO2 | | MW: | 179.64 | | EINECS: | | | Product Categories: | Piperidine | | Mol File: | 71985-80-3.mol |  |
| | 1-Methylpiperidine-4-carboxylic acid hydrochloride Chemical Properties |
| Melting point | 226-228°C (dec.) | | storage temp. | Inert atmosphere,Room Temperature | | form | solid | | color | Off-white | | InChI | InChI=1S/C7H13NO2.ClH/c1-8-4-2-6(3-5-8)7(9)10;/h6H,2-5H2,1H3,(H,9,10);1H | | InChIKey | NLUDEWJJEMHIIL-UHFFFAOYSA-N | | SMILES | N1(C)CCC(C(O)=O)CC1.[H]Cl | | CAS DataBase Reference | 71985-80-3(CAS DataBase Reference) |
| | 1-Methylpiperidine-4-carboxylic acid hydrochloride Usage And Synthesis |
| Chemical Properties | Off-white solid | | Synthesis |
The synthesis method of 1-Methylpiperidine-4-carboxylic acid Hydrochloride is shown below: Charge isonipecotic acid, palladium, and purified water into a reaction vessel. Heat the resulting mixture to 90 to 95° C. Charge formic acid and formaldehyde to the vessel. Cool the resulting mixture to 20 to 30° C. Filter the reaction mixture through GF/F. Wash the filter cake with purified water. Concentrate the combined filtrates to ca 2 vol at atmospheric pressure. Adjust the temperature 65 to 75° C. Charge conc—hydrochloric acid to the vessel. Charge acetonitrile to the vessel at ≧70° C. and concentrate the solution to ca 2 vol at atmospheric pressure. Charge acetonitrile to the vessel. Moreover, concentrate the solution at atmospheric pressure to ca 2 vol. Charge acetonitrile to the vessel. Moreover, concentrate the solution at atmospheric pressure to ca 3 vol. Check the water content by KF analysis of the supernatant liquors using AX reagent. Cool the reaction mixture to 20 to 25° C. Stir the reaction mixture for 1 to 2 hours. Filter the reaction mixture. Wash the filter cake with acetonitrile. Dry the product up to 50° C. until ≦0.5% w/w by LOD and ≦0.2% w/w water.
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| | 1-Methylpiperidine-4-carboxylic acid hydrochloride Preparation Products And Raw materials |
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