|
|
| | Diammonium glycyrrhizinate Basic information |
| Product Name: | Diammonium glycyrrhizinate | | Synonyms: | 18A-DIAMMONIUM GLYCYRRHIZINATE;Diammonium glycyrrhizinate;DiaMMoniuM Glycyrrhizate;a-D-Glucopyranosiduronic acid;18α-DIAMMONIUM GLYCYRRHIZINATE;Diammonium Glycyrrhizinat;N-(3-CHLOROBENZYL)-N-PHENYLBENZENESULFONAMIDE;Diammonium Glycyrrhizinate for Injection | | CAS: | 79165-06-3 | | MF: | C42H65NO16 | | MW: | 839.97 | | EINECS: | 1308068-626-2 | | Product Categories: | | | Mol File: | 79165-06-3.mol |  |
| | Diammonium glycyrrhizinate Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white |
| | Diammonium glycyrrhizinate Usage And Synthesis |
| Description | Diammonium Glycyrrhizinate is the diammonium salt of glycyrrhizin and the active constituent in the traditional Chinese medicinal herb Glycyrrhiza uralensis (Chinese liquorice or Gan-Cao) with anti-inflammatory, antioxidant and hepatoprotective properties. Diammonium glycyrrhizinate (DG) is slowly metabolized within the cells into glycyrrhetic acid, which inhibits enzymes that control cortisol metabolism and contributes to this agent's anti-inflammatory effect. Although the exact mechanism of action remains to be fully elucidated, DG may prevent or reduce hepatotoxicity via the scavenging of free radicals. This agent also upregulates the expression of transcription coactivator PGC-1alpha and modulates hepatic enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase and glutathion peroxidase. | | Occurrence | Diammonium glycyrrhizinate, a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). | | Uses | Diammonium glycyrrhizinate (DG) is an ammonium salt preparation of 18-alpha-glycyrrhizin—exhibits antiinflammation, immunomodulation, anti-anaphylaxis, and membranous protection effects.Currently, the family of glycyrrhizin is used in clinical practice as an effective liver protector against most hepatic diseases such as chronic viral hepatitis, drug-induced liver injury, nonalcoholic fatty liver disease, autoimmune hepatitis, and hepatocellular carcinoma. |
| | Diammonium glycyrrhizinate Preparation Products And Raw materials |
|