PJ-34
| 中文名稱 | PJ-34 |
|---|---|
| 中文同義詞 | N-(6-氧代-5,6-二氫菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺;PJ34(游離);2-(二甲基氨基)-N-(6-氧代-5,6-二氫菲啶-2-基)乙酰胺;化合物PJ34;2-(二甲氨基)-N-(6-氧代-5,6-二氫菲-2-基)乙酰胺;PJ34,PARPL/2 抑制劑;化合物PJ34,10 MM DMSO 溶液 |
| 英文名稱 | PJ-34 |
| 英文同義詞 | N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL;N-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE;PJ-34;PJ34(free base);Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide PJ 34;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide |
| CAS號 | 344458-19-1 |
| 分子式 | C17H17N3O2 |
| 分子量 | 295.34 |
| EINECS號 | 604-604-1 |
| 相關(guān)類別 | 小分子抑制劑，天然產(chǎn)物;DNA損傷;Inhibitors |
| Mol文件 | Mol File |
| 結(jié)構(gòu)式 |  |
PJ-34 性質(zhì)
| 儲存條件 | Sealed in dry,Store in freezer, under -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至卡其色 |
|
PARP 110 nM (IC 50 ) |
PARP-2 86 nM (IC 50 ) |
PARP-1 110 nM (IC 50 ) |
PJ34 inhibits the PARP enzyme activity with an IC 50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10 -7 to 10 -5 M.
To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-13688A | PJ34 | 344458-19-1 | 5 mg | 356元 |
| 2025/02/08 | HY-13688A | PJ-34 PJ34 | 344458-19-1 | 10mg | 570元 |