- Procyclidine
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- $2500.00 / 100mg
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2025-04-27
- CAS:77-37-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | procyclidine Basic information |
| Product Name: | procyclidine | | Synonyms: | Kemadrine;Vagosin;α-Cyclohexyl-α-phenyl-1-pyrrolidine-1-propanol;1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;procyclidine;Tricyclamol;1-Pyrrolidinepropanol, α-cyclohexyl-α-phenyl-;procyclidine USP/EP/BP | | CAS: | 77-37-2 | | MF: | C19H29NO | | MW: | 287.44 | | EINECS: | 201-023-0 | | Product Categories: | | | Mol File: | 77-37-2.mol |  |
| | procyclidine Chemical Properties |
| Melting point | 85.5-86.5° | | Boiling point | 429.73°C (rough estimate) | | density | 0.9954 (rough estimate) | | refractive index | 1.5180 (estimate) | | pka | 14.21±0.29(Predicted) | | Water Solubility | 1.055mg/L(22.5 ºC) |
| | procyclidine Usage And Synthesis |
| Uses | Antiparkinsonian; relaxant (skeletal
muscle). | | Definition | ChEBI: A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3. | | Brand name | Kemadrin (Monarch). | | Synthesis | Procyclidine, 1-cyclohexyl-1-phenyl-3-pirrolidinopropan-1-ol (10.2.3), is
synthesized in the exact same manner, except beginning with 2-(1-pyrrolidino) propiophenone [28–32]. | | in vivo | Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether[1].
| Animal Model: | Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs[1] | | Dosage: | 0.3-6.0 mg/kg | | Administration: | Subcutaneous injection; once | | Result: | Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively.
Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus.
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| | IC 50 | NMDA Receptor |
| | procyclidine Preparation Products And Raw materials |
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