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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >PROSTAGLANDIN D2

PROSTAGLANDIN D2

PROSTAGLANDIN D2 Suppliers list
Company Name: TargetMol Chemicals Inc.
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Email: marketing@targetmol.com
Products Intro: Product Name:Prostaglandin D2;PGD2
CAS:41598-07-6
Purity:98.00% Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:PROSTAGLANDIN D2
CAS:41598-07-6
Purity:98.8%min emma@coreychem.com Package:1KG;2.18USD
Company Name: TargetMol Chemicals Inc.
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Email: support@targetmol.com
Products Intro: Product Name:Prostaglandin D2
CAS:41598-07-6
Purity:100% Package:100μg;223USD
Company Name: Aladdin Scientific
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Products Intro: Product Name:Prostaglandin D2
CAS:41598-07-6
Purity:>=99% Package:$189.9/1mg;$659.9/5mg;Bulk package Remarks:99%
Company Name: J & K SCIENTIFIC LTD.  
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Products Intro: Product Name:Prostaglandin D2
CAS:41598-07-6
Package:1Mg,2.5Mg

PROSTAGLANDIN D2 manufacturers

  • Prostaglandin D2
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  • $223.00 / 100μg
  • 2024-11-19
  • CAS:41598-07-6
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  • Purity: 100%
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PROSTAGLANDIN D2 Basic information
Product Name:PROSTAGLANDIN D2
Synonyms:9,15-dihydroxy-11-oxo-,(5z,9-alpha,13e,15s)-prosta-13-dien-1-oicacid;prostaglandin D2 cell culture tested;prostaglandind2synthetichygroscopic;(5z,9α,13e,15s)-9,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid;7-[(1R,2R,5S)-5-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid;PGD2, (5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid;(5Z,13E,15S)-9α,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid;Prostaglandin D2,(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid, PGD2
CAS:41598-07-6
MF:C20H32O5
MW:352.47
EINECS:636-995-9
Product Categories:
Mol File:41598-07-6.mol
PROSTAGLANDIN D2 Structure
PROSTAGLANDIN D2 Chemical Properties
Melting point 68°C
Boiling point 406.07°C (rough estimate)
alpha +7.5°(D/21℃)(c=1,THF)
density 1.0601 (rough estimate)
refractive index 1.6120 (estimate)
storage temp. -20°C
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly), THF (Slightly)
pka4.76±0.10(Predicted)
form White solid
color White to Light Orange
biological sourcesynthetic
BRN 2170623
Stability:Light Sensitive
Safety Information
Hazard Codes T
Risk Statements 60-22
Safety Statements 53-22-26-36
WGK Germany 3
RTECS UK7930000
10
MSDS Information
ProviderLanguage
SigmaAldrich English
PROSTAGLANDIN D2 Usage And Synthesis
DescriptionProstaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 μM.
UsesProstaglandin D2 is a fatty acid compound present in the human body. Elevated levels of localized Prostaglandin D2 has been linked to hair loss and growth inhibition. It has also been seen to contribute to the activity of allergic asthma.
DefinitionChEBI: A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- s ereoisomer).
Biochem/physiol ActionsPrimary prostaglandin in brain; induces inflammation; stimulates adenylyl cyclase.
in vivo

Prostaglandin D2 (PGD2; infused into the lateral ventricle; 5-50 pmol/min; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice[2].

Animal Model:Male WT and A2AR KO mice of the inbred C57BL/6 strain (weighing 23-27 g, 11-13 weeks old)[1]
Dosage:5, 10, 20, or 50 pmol/min
Administration:Infused into the lateral ventricle; for 6 hours between 20:00 and 2:00
Result:Induced sleep-wake profiles.
IC 50DP; Human Endogenous Metabolite
Tag:PROSTAGLANDIN D2(41598-07-6) Related Product Information
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