JW-55
| 中文名稱 | JW-55 |
|---|---|
| 中文同義詞 | N-[4-[[[[四氫-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺;N-[4-[[[[四氫-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺(JW55);Β-CATENIN抑制劑(JW 55);N-(4-((4-(4-甲氧基苯基)四氫-2H-吡喃-4-基)甲基氨基甲?；?苯基)呋喃-2-甲酰胺;N-(4-(((4-(4-甲氧基苯基)四氫-2H-吡喃-4-基)甲基)氨甲酰)苯基)呋喃-2-甲酰胺;JW55,罐錨酶抑制劑;化合物 JW55;N-(4-(((4-(4-甲氧基苯基)四氫-2H-吡喃-4-基)甲基)氨甲酰)苯基)呋喃-2-甲酰胺/Β-CATENIN抑制劑(JW 55) |
| 英文名稱 | JW55 |
| 英文同義詞 | JW55;N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide;N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE;N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;JW55 N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;JW 55, >=98%;N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid;Tankyrase1/2 Inhibitor IV, JW55 |
| CAS號 | 664993-53-7 |
| 分子式 | C25H26N2O5 |
| 分子量 | 434.48 |
| EINECS號 | |
| 相關(guān)類別 | 小分子抑制劑;小分子抑制劑，天然產(chǎn)物;細(xì)胞生物學(xué)試劑;Inhibitors;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 664993-53-7.mol |
| 結(jié)構(gòu)式 |  |
JW-55 性質(zhì)
| 沸點(diǎn) | 572.6±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.235±0.06 g/cm3(Predicted) |
| 儲存條件 | Inert atmosphere,2-8°C |
| 溶解度 | DMSO：可溶15mg/mL，澄清 |
| 酸度系數(shù)(pKa) | 12.41±0.70(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
JW55是一種有效的、選擇性經(jīng)典Wnt信號通路抑制劑，通過抑制TNKS1/2的PARP區(qū)域發(fā)揮作用。
| Target | Value |
|
Wnt
() |
JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC 50 value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells.
JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication in Xenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/05/22 | 46785 | JW55, 95% JW55, 95% | 664993-53-7 | 100mg | 6757元 |
| 2025/05/22 | HY-13968 | JW 55 | 664993-53-7 | 5 mg | 248元 |