中文同義詞:
鹽酸伊伐布雷啶;鹽酸伊伐布雷定IVABRADINE(研發(fā)中);鹽酸伊伐布雷定及中間體;鹽酸伊伐布雷定(依法布雷定);依伐布雷定鹽酸鹽;鹽酸依伐布雷定;鹽酸伊伐布雷;鹽酸伊伐布雷定/鹽酸依法布雷定
英文名稱:
Ivabradine hydrochloride
英文同義詞:
Ivabradine HCl;Ivabradine hydrochloride;3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride;Ivabradine hydrochloride, >=99%;IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR;Ivabradine hydrochloride, 98%, a If inhibitor;3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride;Corlentor
相關(guān)類別:
小分子抑制劑，天然產(chǎn)物;醫(yī)藥原料藥;醫(yī)藥原料;醫(yī)藥中間體;原料藥;小分子抑制劑;神經(jīng)信號;細(xì)胞生物學(xué)試劑;Intermediates Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Heterocycles;Cardiovascular APIs;Inhibitors;心臟;藥物雜質(zhì)及中間體;原料;醫(yī)藥、農(nóng)藥及染料中間體;醫(yī)藥化工類
比旋光度
58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
溶解度
H2O: ≥5mg/mL (warmed)
旋光性 (optical activity)
[α]/D +5 to +9°, c = 1 in DMSO
InChIKey
HLUKNZUABFFNQS-ZMBIFBSDSA-N
CAS 數(shù)據(jù)庫
148849-67-6(CAS DataBase Reference)
用途
鹽酸伊伐布雷定是首個選擇性和特異性調(diào)節(jié)心率抑制劑,對竇房結(jié)有選擇性作用而對心臟內(nèi)傳導(dǎo)、心肌收縮或心室復(fù)極化無作用。
用途
鹽酸伊伐布雷定是依瓦拉定與一摩爾等量的鹽酸合成的鹽酸鹽，用于治療不能耐受-受體阻滯劑和/或心力衰竭的心絞痛患者。
生物活性
Ivabradine HCl (S 16257-2)是一種新型If抑制劑，IC50為2.9 μM，特定有效作用于竇房結(jié)心臟起搏器活性，是一種純粹的心跳速率降低劑。
靶點(diǎn)
Target Value Adrenergic Receptor
體內(nèi)研究
Ivabradine hydrochloride treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression. Ivabradine hydrochloride leads to a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine hydrochloride treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension.
關(guān)鍵字： 鹽酸伊伐布雷定原料;鹽酸伊伐布雷定現(xiàn)貨;鹽酸伊伐布雷定廠家;鹽酸伊伐布雷定檢測;鹽酸伊伐布雷定公示;
江西瑞威爾生物科技有限公司，注冊地江西省峽江縣，在南昌設(shè)有辦事處，武漢設(shè)有分公司。公司依托母公司江右云商豐富的互
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