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喹夫拉朋鈉

喹夫拉朋鈉

中文名稱喹夫拉朋鈉
中文同義詞喹夫拉朋鈉
英文名稱sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate
英文同義詞sodium 3-[1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)-3-tert-butylsulfanyl-indol-2-yl]-2,2-dimethyl-propanoate;1-[(4-Chlorophenyl)Methyl]-3-[(1,1-diMethylethyl)thio]-α,α-diMethyl-5-(2-quinolinylMethoxy)-1H-Indole-2-propanoic Acid SodiuM Salt;MK 591;Quiflapon SodiuM;QUIFLAPON SODIUM; MK-591; MK 591;QUIFLAPON SODIUM (MK591);MK-591 sodium
CAS號(hào)147030-01-1
分子式C34H34ClN2NaO3S
分子量0
EINECS號(hào)
相關(guān)類別Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol文件147030-01-1.mol
結(jié)構(gòu)式喹夫拉朋鈉 結(jié)構(gòu)式

喹夫拉朋鈉 性質(zhì)

儲(chǔ)存條件-20°C
溶解度DMSO : 50 mg/mL (82.08 mM; 需要超聲波)H2O : < 0.1 mg/mL (不溶)
形態(tài)粉末
顏色白色至米白色

喹夫拉朋鈉 用途與合成方法

Quiflapon sodium (MK-591 sodium) 是選擇性的,特異性的 FLAP 抑制劑。Quiflapon sodium 是一種有效的,具有口服活性的白三烯生物合成 (leukotriene biosynthesis) 抑制劑。誘導(dǎo)細(xì)胞凋亡 (apoptosis)。

Quiflapon sodium (MK591) and SB203580 are able to block SEB-induced human PBMC cell proliferation. Quiflapon sodium (MK591) down regulates three genes [for cathepsin L, IL-17 and guanylate binding protein (GBP)-2] that are up regulated by SEB. Quiflapon sodium (MK591) undergoes apoptosis within hours of treatment. Quiflapon sodium also induces rapid activation of the stress kinase, c-Jun N-terminal kinase (JNK), which plays an important role in the apoptosis process. Quiflapon sodium triggers apoptosis in prostate cancer cells without inhibition of PI3K-Akt, or ERK. Moreover, Quiflapon sodium and LY294002 exert synergistic effect in inducing apoptosis in prostate cancer cells. Quiflapon sodium (MK591) influences cAMP response element-binding protein but not Sp1.

Hyperoxia groups of mice treated with Quiflapon sodium (MK591) (20, 40 mg/kg) show alveolarization that resembles that of room air controls while untreated hyperoxia groups show definite evidence of aberrant alveolarization but no inflammation. Comparison of the Aβ-immunopositive areas between the placebo and Quiflapon sodium (MK591) (320 mg/kg)-treated group reveals a statistically significant reduction of the amyloid burden in the treated mice. Quiflapon sodium also has a significant reduction in brain levels of IL-1β. Mice treated with Quiflapon sodium show a statistically significant decrease in the steady-state levels of total CREB and its phosphorylated form at Ser133.

安全信息

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-50714Quiflapon sodium1 mg465元
2024/11/08HY-50714喹夫拉朋鈉
Quiflapon sodium
147030-01-15mg950元

喹夫拉朋鈉 上下游產(chǎn)品信息

"喹夫拉朋鈉"相關(guān)產(chǎn)品信息
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