PF 1022A
| 中文名稱 | PF 1022A |
|---|---|
| 中文同義詞 | 化合物 T16497;環(huán)(D-2-羥基丙?；?N-甲基-L-亮氨?；?3-苯基-D-2-羥基丙?；?N-甲基-L-亮氨酰基-D-2-羥基丙?；?N-甲基-L-亮氨酰基-3- 苯基-D-2-羥基丙?；?N-甲基-L-亮氨酰);(3S,6R,9S,12R,15S,18R,21S,24R)-6,18-二芐基-3,9,15,21-四異丁基-4,10,12,16,22,24-六甲基-1,7,13,19-四氧雜-4,10,16,22-四氮雜環(huán)二十四烷-2,5,8,11,14,17,20,23-八酮;化合物 PF 1022A |
| 英文名稱 | PF 1022A |
| 英文同義詞 | PF 1022A;Cyclo(D-2-hydroxypropanoyl-N-methyl-L-leucyl-3-phenyl-D-2-hydroxypropanoyl-N-methyl-L-leucyl-D-2-hydroxypropanoyl-N-methyl-L-leucyl-3-phenyl-D-2-hydroxypropanoyl-N-methyl-L-leucyl);PF1022A; PF-1022A;Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl];(3S,6R,9S,12R,15S,18R,21S,24R)-6,18-Dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclotetracosan-2,5,8,11,14,17,20,23-octaone;(3S,6R,9S,12R,15S,18R,21S,24R)-6,18-dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone |
| CAS號 | 133413-70-4 |
| 分子式 | C52H76N4O12 |
| 分子量 | 949.2 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 133413-70-4.mol |
| 結(jié)構(gòu)式 |  |
PF 1022A 性質(zhì)
| 熔點 | 89-92 °C |
|---|---|
| 沸點 | 1086.6±65.0 °C(Predicted) |
| 密度 | 1.070±0.06 g/cm3(Predicted) |
| 儲存條件 | Desiccate at -20°C |
| 溶解度 | 二甲基亞砜：43mg/mL |
| 形態(tài) | 結(jié)晶固體 |
| 酸度系數(shù)(pKa) | -1.09±0.70(Predicted) |
| 顏色 | 白色至米白色 |
PF 1022A 是一種通過發(fā)酵菌絲菌絲體產(chǎn)生的具有廣譜驅(qū)蟲特性的肽。PF 1022A 是形成通道的離子載體。PF 1022A 對雞中的 Ascaridia galli 具有強大的驅(qū)蟲活性。PF 1022也可用于血管平滑肌病研究。
PF 1022A binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. Furthermore, PF 1022A binds to GABA receptors, which might contribute to the anthelmintic effect.
In vitro, PF 1022A shows low activity on embryonation but significantly inhibits egg hatch (10 and 100 μg/mL), whereas albendazole (10 and 100 μg/mL) reveales statistically significant inhibitions of both embryonation and egg hatch. PF 1022A (1-100 μg/mL) completely inhibits larval movement at most examination points.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-12361 | 133413-70-4 PF 1022A | 133413-70-4 | 5mg | 2000元 |
| 2024/11/08 | HY-12361 | 133413-70-4 PF 1022A | 133413-70-4 | 10mg | 3200元 |