甲磺酸阿米三嗪
| 中文名稱 | 甲磺酸阿米三嗪 |
|---|---|
| 中文同義詞 | N,N'-二烯丙基-6-[4-[二(4-氟苯基)甲基]哌嗪-1-基]-1,3,5-三嗪-2,4-二胺二甲磺酸鹽;甲磺酸阿米三嗪;二甲基阿咪三嗪;二甲磺酸阿米三嗪(標準品);N2,N4-二烯丙基-6-(4-(雙(4-氟苯基)甲基)哌嗪-1-基)-1,3,5-三嗪-2,4-二胺二甲磺酸鹽 |
| 英文名稱 | Almitrine dimesylate |
| 英文同義詞 | ALMITRINE BISMESYLATE;ALMITRINE DIMESYLATE;2,4-bis(allylamino)-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine dimethanesulfonate;n,n'-diallyl-6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1,3,5-triazine-2,4-diamine dimethanesulphonate;ALMITRINE DIMESILATE;Mesylate AlMitrine;N2,N4-Diallyl-6-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1,3,5-triazine-2,4-diamine dimethanesulfonate;Almitrine bismethanesulfonate |
| CAS號 | 29608-49-9 |
| 分子式 | C28H37F2N7O6S2 |
| 分子量 | 669.76 |
| EINECS號 | 249-726-1 |
| 相關類別 | 藥物標準品;醫(yī)藥原料;醫(yī)藥中間體;標準品;中藥對照品;原料藥;化學試劑;醫(yī)用原料 |
| Mol文件 | 29608-49-9.mol |
| 結(jié)構(gòu)式 |  |
甲磺酸阿米三嗪 性質(zhì)
| 熔點 | 243° (dec) |
|---|---|
| 儲存條件 | Sealed in dry,Room Temperature |
| 溶解度 | 可溶于氯仿（少許）、甲醇（少許） |
| 形態(tài) | 固體 |
| 顏色 | 白色 |
K + channel
Almitrine inhibits the activity of a high-conductance (152±13 pS), Ca 2+ -dependent K + channel by decreasing its open probability. The IC 50 value of the effect is 0.22 μM. The inhibitory effect of Almitrine on Ca 2+ -dependent K + channels also is observed in GH3 cells. Almitrine at concentrations up to 10 μM does not affect whole-cell voltage-dependent K + , Ca 2+ , or Na + currents in rat or rabbit cells. However, this concentration of Almitrine significantly inhibits the Ca 2+ -dependent component of K + currents in rat chemoreceptor cells.
Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio.
安全信息
| 毒性 | LD50 in mice: 210 mg/kg i.v., 390 mg/kg i.p., >2 g/kg orally (Regnier) |
|---|