- NETROPSIN
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- $1.00 / 1kg
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2025-04-23
- CAS:1438-30-8
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10 mt
- NETROPSIN
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- $0.00 / 25KG
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2025-03-21
- CAS:1438-30-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- NETROPSIN
-
- $1.00 / 1KG
-
2020-02-02
- CAS:1438-30-8
- Min. Order: 1KG
- Purity: 99%HPLC
- Supply Ability: 200KG
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| | NETROPSIN Basic information |
| Product Name: | NETROPSIN | | Synonyms: | NETROPSIN;ia887;k-117;n,4’-bi(pyrrole-2-carboxamide),n’-(2-carbamoylethyl)-4-((2-guanidinoacetimidoy;t1384;NETROPSIN ULTRA PURE GRADE 98+%;ultrapuregrade;Congocidin, Sinanomycin | | CAS: | 1438-30-8 | | MF: | C18H26N10O3 | | MW: | 430.46 | | EINECS: | 634-294-2 | | Product Categories: | | | Mol File: | 1438-30-8.mol |  |
| | NETROPSIN Chemical Properties |
| Melting point | 171-173℃ | | Boiling point | 544.74°C (rough estimate) | | density | 1.3374 (rough estimate) | | refractive index | 1.6500 (estimate) | | storage temp. | −20°C | | solubility | H2O: 1 mg/mL | | form | powder | | pka | 14.37±0.70(Predicted) | | color | faint yellow | | EPA Substance Registry System | Netropsin (1438-30-8) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | DW2973000 | | Toxicity | LD50 oral in mouse: 300mg/kg |
| | NETROPSIN Usage And Synthesis |
| Uses | Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity[1][2]. | | References | [1] Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta. 1991 Aug 27;1090(1):52-60. DOI:10.1016/0167-4781(91)90036-l
[2] Finlay A C, et al. Netropsin, a new antibiotic produced by a Streptomyces. Journal of the American Chemical Society, 1951, 73(1): 341-343. |
| | NETROPSIN Preparation Products And Raw materials |
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