天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

鹽酸KHS101

鹽酸KHS101

中文名稱鹽酸KHS101
中文同義詞鹽酸KHS101
英文名稱KHS101 hydrochloride
英文同義詞KHS101 hydrochloride;KHS 101,inhibit,Fibroblast growth factor receptor,Inhibitor,FGFR,KHS101,KHS-101 hydrochloride,KHS101 hydrochloride,KHS-101
CAS號1784282-12-7
分子式C18H22ClN5S
分子量375.92
EINECS號
相關類別標準品
Mol文件1784282-12-7.mol
結構式鹽酸KHS101 結構式

鹽酸KHS101 性質

溶解度在 DMSO 中溶解度為 50 mM,在乙醇中溶解度為 50 mM
形態(tài)固體
顏色白色至米白色

鹽酸KHS101 用途與合成方法

KHS101是TACC3的小分子抑制劑,TACC3是中心體微管動態(tài)網(wǎng)絡中的關鍵組分。
TargetValue
TACC3
()

KHS101 increases neuronal differentiation of adherently cultured rat NPCs in a dose-dependent fashion (EC 50 ~1 μM). KHS101-induced neuron formation (40-60% TuJ1+ cells at 1.5–5 μM KHS101) is also observed under neurosphere-forming conditions in secondary neurospheres derived from both the hippocampus and the subventricular zone (SVZ) of adult rats. Moreover, hippocampal NPCs treated with KHS101 and cultured adherently on microelectrode arrays for 12 d exhibit neuronal morphologies as well as spontaneous spiking activity, hence indicating the presence of functional, maturing neurons. KHS101 markedly attenuates tumor cell growth as compared to the cells treated with the vehicle [dimethyl sulfoxide (DMSO)]. TACC3 is a known target of KHS101 in rodent neural progenitor cells. KHS101 has been shown to cause cellular destabilization of TACC3, hence reducing endogenous TACC3 protein levels over time .

Tumor cell proliferation is markedly reduced in KHS101-treated tumors (about twofold). KHS101-treated tumors show signs of elevated cell death (reduced cellularity/increased pyknosis) compared with tumors treated with vehicle control. KHS101 treatment markedly reduces both frontal-to-caudal tumor expansion and corpus callosum invasion of vimentin-positive GBM1 cells. It is also found that the survival of animals carrying GBMX1 tumors (established 2 or 6 weeks before treatment) is markedly increased by the KHS101 treatment regimen for 10 weeks. None of the mice have to be removed from the study because of adverse side effects of the treatment. An additional experiment using a continuous KHS101 treatment regimen until the experimental endpoints also shows a marked increase in the survival of GBMX1-bearing animals. Histological endpoint analysis of KHS101- and vehicle-treated animals confirms a significantly decreased tumor size in KHS101-treated mice.

安全信息

MSDS信息

更新日期產品編號產品名稱CAS號包裝價格
2024/11/08HY-10996AKHS101 hydrochloride1 mg386元
2024/11/08HY-10996A鹽酸KHS101
KHS101 hydrochloride
1784282-12-75mg850元

鹽酸KHS101 上下游產品信息

"鹽酸KHS101"相關產品信息
3α-羥基類固醇脫氫酶
主頁 | 企業(yè)會員服務 | 廣告業(yè)務 | 聯(lián)系我們 | 舊版入口 | 中文MSDS | CAS Index | 常用化學品CAS列表 | 化工產品目錄 | 新產品列表 | 評選活動 | HS海關編碼 | MSDS查詢 | 化工站點

Copyright © 2016-2023 ChemicalBook 版權所有  京ICP備07040585號  京公海網(wǎng)安備11010802032676號  

互聯(lián)網(wǎng)增值電信業(yè)務經(jīng)營許可證:京ICP證150597號  互聯(lián)網(wǎng)藥品信息服務資格證編號(京)-非經(jīng)營性-2015-0073  信息系統(tǒng)安全等級保護備案證明(三級)  營業(yè)執(zhí)照公示

根據(jù)相關法律法規(guī)和本站規(guī)定,單位或個人購買相關危險物品應取得有效的資質、資格條件。
參考《應急管理部等多部門關于加強互聯(lián)網(wǎng)銷售危險化學品安全管理的通知 (應急〔2022〕119號)》《互聯(lián)網(wǎng)危險物品信息發(fā)布管理規(guī)定》