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Standard

In the analysis work, it often demanded to apply high-quality compound with the exact content being accurate in order to be compared as the detection control or used to calibrate the instrument, the compound is known as standard sample.
Standard refers to the standard substance used for measuring the potency of biological products. When the production department submits to a higher authority for approval of the quality standard of the biological product, they should also provide the standard sample (indicated in unit (μ)) used for measuring the potency of the tested product.

According to different application, the verification products can be divided into biological standard for the testing of biological products, endocrine drugs, antibiotics and other bioassay and chemical standards including:
1 chemical standards used for calibration of the instrument;
2 chemical reference standards used for calibration of the ultraviolet or infrared spectrum of the drugs;
3 control standards used for the purity test of drugs as well as the impurity control or as the control standards for content determination of the medicine.

In the page 67 of the appendix in the People's Republic of China Pharmacopoeia 1990 1st edition, we can find hundreds kinds of standards including bornyl ester acetate, eugenol and panaxadiol as well as 39 kinds of control medicine for the purify inspection of traditional Chinese medicine, impurity control or the content determination.

International standards
This refers to standard sample, with the potency units of the existing international standard sample potency units as baseline, undergoing further calibration of its potency units on the basis of a wide range of international cooperation. Its potency is expressed in 1U. For a certain product, for the establishment of the first international standard sample, the determination of its potency units should be consulted and decided by the Committee of Experts before the announcement. The international standard is a standard reference substance for worldwide preparation of national standards, so that the international standards can achieve unity.

Reagents and standards
All reagents in the food analysis laboratories should be clearly labeled to indicate the following: 1 name; 2 the date of preparation; 3 Signature from the people in charge; 4 if necessary, we need to add content such as safety and validity and so on.
Most food analysis should use standard sample as reference for qualitative and quantitative determination. The standard sample should be classified according to the following classification methods: 1 international standard; 2 national standards; 3 internal standard; 4 other standards.
Receptacle for reference standards should be clearly affixed to the label, to indicate the following: 1 name; 2 standard document number; 3 Opening times; 4 Validity; 5 Signature.
In addition, the laboratory should keep all the necessary specific files for all the necessary reference standards.
Capacity analysis standard solution should also be strictly managed. It should be clearly posted on all the standard solution containers with labels to indicate: 1 name; 2 concentration; 3 formulation date; 4 No of formulated procedures; 5 storage conditions; 6 validity; 7 Signature from people in charge.

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Structure Chemical Name CAS MF
Aztreonam Impurity 3 Aztreonam Impurity 3
Aztreonam Impurity 9 Aztreonam Impurity 9
Bendamustine Impurity 24 Bendamustine Impurity 24
Bosutinib Impurity 4 Bosutinib Impurity 4 142072-71-7 C10H11NO4
Cefazolin EP Impurity L Cefazolin EP Impurity L
Cefoxitin Impurity 2 Cefoxitin Impurity 2
Clotrimazole Impurity 4 Clotrimazole Impurity 4
Dasatinib impurity 29 Dasatinib impurity 29 1417651-54-7 C21H16Cl3N7OS
Erlotinib Impurity 58 Erlotinib Impurity 58 2246399-22-2 C10H12N2O3
Lamivudine Impurity 4 Lamivudine Impurity 4
Olaparib Impurity 37 Olaparib Impurity 37
Oseltamivir Impurity 3 Oseltamivir Impurity 3
Phenylephrine Impurity 2 Phenylephrine Impurity 2 C9H13NO2
Pitavastatin Impurity 23 Pitavastatin Impurity 23 1467166-39-7 C28H28FNO4
Pregabalin Impurity 24 Pregabalin Impurity 24
Rocuronium Bromide Impurity 11 Rocuronium Bromide Impurity 11
Rocuronium Bromide Impurity 24 Rocuronium Bromide Impurity 24
Rosuvastatin EP Impurity L Rosuvastatin EP Impurity L
Timolol EP Impurity J Timolol EP Impurity J
Trimetazidine Impurity 7 Trimetazidine Impurity 7
Apremilast Impurity TNB Apremilast Impurity TNB
Atracurium Impurity N Atracurium Impurity N
Avibactam Impurity X Avibactam Impurity X
Cefazolin Impurity L Cefazolin Impurity L
Ceftazidime hetero trans oxidation Impurity Ceftazidime hetero trans oxidation Impurity
Regorafenib Impurity 17 Regorafenib Impurity 17
Ropivacaine Impurity 45 Ropivacaine Impurity 45 2726971-51-1
Sildenafil Impurity 17 Sildenafil Impurity 17 C22H30N6O4S
Sugammadex sodium Org199074-1 Impurity Sugammadex sodium Org199074-1 Impurity
Sugammadex sodium Org238832-1 Impurity Sugammadex sodium Org238832-1 Impurity
Afatinib impurity 33 Afatinib impurity 33
Avibactam Impurity 38 Avibactam Impurity 38 2241730-86-7 C20H29BrN2O5
Butyphthalide impurity 27 Butyphthalide impurity 27 33704-16-4 C12H12O5
Butyphthalide impurity 35 Butyphthalide impurity 35
Canagliflozin Impurity 31 Canagliflozin Impurity 31
Celecoxib Impurity 21 Celecoxib Impurity 21 2055787-31-8 C17H12F3N3O3S
Emtricitabine Impurity CFTU2 Emtricitabine Impurity CFTU2
Febuxostat Impurity 88 Febuxostat Impurity 88
Gefitinib Impurity S Gefitinib Impurity S
Ibrutinib Impurity 15 Ibrutinib Impurity 15 1288338-97-5 C47H46N12O3
LCZ696(valsartan + sacubitril) impurity 34 LCZ696(valsartan + sacubitril) impurity 34
Lenvatinib Impurity 27 Lenvatinib Impurity 27
Montelukast sodium impurity H Montelukast sodium impurity H
Regorafenib Impurity 25 Regorafenib Impurity 25
Regorafenib Impurity 33 Regorafenib Impurity 33
Sitafloxacin Impurity ZZ-A-02 Sitafloxacin Impurity ZZ-A-02
Solifenacin impurity 19 Solifenacin impurity 19 1422505-78-9 C17H17NO
Tofacitinib Impurity 93 Tofacitinib Impurity 93
Topiroxostat Impurity 30 Topiroxostat Impurity 30
Sitafloxacin Impurity 8 Sitafloxacin Impurity 8
Budesonide Impurity 7 Budesonide Impurity 7 3949-79-9 C23H28O7
Azacitidine Impurity 34 Azacitidine Impurity 34 105330-94-7 C9H14N4O5
Diazepam Impurity 1 Diazepam Impurity 1 36020-94-7 C16H15ClN2O2
Rosuvastatin Related Compound 8 Rosuvastatin Related Compound 8 521974-01-6 C13H23ClO4
Apixaban Impurity 24 Apixaban Impurity 24 2264018-89-3 C25H26N4O6
ammonium 1-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxylate ammonium 1-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxylate 2227107-89-1 C16H18N4O4
Aztreonam Impurity 8 Aztreonam Impurity 8
(1s,4s)-4-((2-amino-4-bromobenzyl)amino)cyclohexan-1-ol hydrochloride (1s,4s)-4-((2-amino-4-bromobenzyl)amino)cyclohexan-1-ol hydrochloride C13H20BrClN2O
Pitavastatin Impurity 18 Sodium Salt Pitavastatin Impurity 18 Sodium Salt 2276678-27-2 C25H25FNNaO5
Moxifloxacin Impurity 67 Moxifloxacin Impurity 67 1430075-14-1 C10H16ClNO3
Landiolol impurity Landiolol impurity
Irinotecan Impurity K Irinotecan Impurity K
Palbociclib  Impurity 28 Palbociclib Impurity 28
Afatinib impurity 40 Afatinib impurity 40
Vildagliptin Impurity 37 Vildagliptin Impurity 37
Tazobactam Impurity B Tazobactam Impurity B 115546-66-2 C10H12N4O5S
Brexpiprazole Impurity 20 Brexpiprazole Impurity 20 105685-34-5 C12H14N2O
Pralatrexate Impurity 13 Pralatrexate Impurity 13
Pralatrexate Impurity 18 Pralatrexate Impurity 18
Pitavastatin Impurity 50 Pitavastatin Impurity 50
Pitavastatin Impurity 58 Pitavastatin Impurity 58
Lenvatinib Impurity 41 Lenvatinib Impurity 41
Tazobactam Impurity 12 Tazobactam Impurity 12
Tofacitinib Impurity 103 Tofacitinib Impurity 103
Posaconazole impurity 69 Posaconazole impurity 69
Crisaborole Impurity 3 Crisaborole Impurity 3
Canagliflozin Impurity 59 Canagliflozin Impurity 59
Canagliflozin Impurity 64 Canagliflozin Impurity 64
Hydroxychloroquine Impurity I Hydroxychloroquine Impurity I
Sitafloxacin Impurity 22 Sitafloxacin Impurity 22
Levetiracetam Impurity 24 Levetiracetam Impurity 24
Selexipag Impurity 5 Selexipag Impurity 5 2928611-79-2
Levosimendan Impurity 11 Levosimendan Impurity 11
Cabozantinib impurity O Cabozantinib impurity O
(41S,12S,13aS)-12-(ethoxycarbonyl)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydroindolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine 4(1H)-oxide (41S,12S,13aS)-12-(ethoxycarbonyl)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydroindolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine 4(1H)-oxide 52341-36-3 C22H28N2O4
Rotigotine Impurity 5 Rotigotine Impurity 5
Rotigotine Impurity 10 Rotigotine Impurity 10
(S)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid (S)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid 64471-43-8 C13H16O3
Olprinone Impurity 6 Olprinone Impurity 6
Trenbolone Acetate Process Impurity 4 Trenbolone Acetate Process Impurity 4 5218-51-9 C18H24O2
Cilastatin Impurity 6 Cilastatin Impurity 6
Sitagliptin Impurity 77 Sitagliptin Impurity 77 382638-00-8 C11H21NO7S
Trimetazidine Impurity 6 Trimetazidine Impurity 6
Oseltamivir Impurity 50 Oseltamivir Impurity 50 651324-06-0 C24H42N2O3
Tamsulosin impurity 6 Tamsulosin impurity 6 C20H28N2O5S
Flucloxacillin Impurity 6 Flucloxacillin Impurity 6
Ipratropium bromide Impurity 3 Ipratropium bromide Impurity 3 C20H29Br2NO3
Afatinib Impurity 54 Afatinib Impurity 54
Aprepitant Impurity 32 Aprepitant Impurity 32
Atorvastatin Impurity 34 Atorvastatin Impurity 34 C66H68CaF2N4O10
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