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ChemicalBook >> CAS DataBase List >> Tolvaptan

Tolvaptan

Tolvaptan price.
  • $32 - $2600
  • Product name: Tolvaptan
  • CAS: 150683-30-0
  • MF: C26H25ClN2O3
  • MW: 448.94
  • EINECS:691-537-5
  • MDL Number:MFCD09838782
  • Synonyms:N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide;Tolvaptan;N-[4-[(5R)-7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl]-2-methylbenzamide;N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-Methylphenyl)-2-MethylbenzaMide;OPC 41061;OPC-41061;SaMsca;Tolvaptan Tablets
35 prices
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Brand
  • Abosyn
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Chemtos
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Oakwood
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 1mg
  • 5mg
  • 10MG
  • 25mg
  • 100mg
  • 50mg
  • 50
  • 1g
  • 5g
  • 10g
  • ManufacturerAbosyn
  • Product number61-2904
  • Product descriptionN-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 95%-98%
  • Packaging1g
  • Price$576
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberB720
  • Product descriptionTolvaptan
  • Packaging25mg
  • Price$152
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ20620
  • Product descriptionTolvaptan
  • Packaging10g
  • Price$447
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024498
  • Product descriptionTOLVAPTAN 95.00%
  • Packaging10MG
  • Price$190.05
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2300
  • Product descriptionTolvaptan
  • Packaging50mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2634
  • Product descriptionTolvaptan
  • Packaging10mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2634
  • Product descriptionTolvaptan
  • Packaging100mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2634
  • Product descriptionTolvaptan
  • Packaging1g
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBT164486
  • Product descriptionTolvaptan
  • Packaging10mg
  • Price$126
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBT164486
  • Product descriptionTolvaptan
  • Packaging50mg
  • Price$338
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19691
  • Product descriptionTolvaptan ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19691
  • Product descriptionTolvaptan ≥98%
  • Packaging5mg
  • Price$86
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19691
  • Product descriptionTolvaptan ≥98%
  • Packaging10mg
  • Price$153
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19691
  • Product descriptionTolvaptan ≥98%
  • Packaging25mg
  • Price$335
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM158523
  • Product descriptionN-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]-azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 98%
  • Packaging10mg
  • Price$117
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM158523
  • Product descriptionN-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]-azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 98%
  • Packaging50mg
  • Price$358
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Abosyn 61-2904 N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 95%-98% 1g $576 2021-12-16 Buy
AK Scientific B720 Tolvaptan 25mg $152 2021-12-16 Buy
AK Scientific J20620 Tolvaptan 10g $447 2021-12-16 Buy
American Custom Chemicals Corporation API0024498 TOLVAPTAN 95.00% 10MG $190.05 2021-12-16 Buy
ApexBio Technology B2300 Tolvaptan 50mg $330 2021-12-16 Buy
AvaChem 2634 Tolvaptan 10mg $35 2021-12-16 Buy
AvaChem 2634 Tolvaptan 100mg $75 2021-12-16 Buy
AvaChem 2634 Tolvaptan 1g $185 2021-12-16 Buy
Biosynth Carbosynth BT164486 Tolvaptan 10mg $126 2021-12-16 Buy
Biosynth Carbosynth BT164486 Tolvaptan 50mg $338 2021-12-16 Buy
Cayman Chemical 19691 Tolvaptan ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 19691 Tolvaptan ≥98% 5mg $86 2024-03-01 Buy
Cayman Chemical 19691 Tolvaptan ≥98% 10mg $153 2024-03-01 Buy
Cayman Chemical 19691 Tolvaptan ≥98% 25mg $335 2024-03-01 Buy
Chemenu CM158523 N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]-azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 98% 10mg $117 2021-12-16 Buy
Chemenu CM158523 N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]-azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 98% 50mg $358 2021-12-16 Buy

Properties

Melting point :219-222°C
Boiling point :594.4±50.0 °C(Predicted)
Density :1.311±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥15mg/mL
form :powder
pka :13.00±0.70(Predicted)
color :white to tan
InChIKey :GYHCTFXIZSNGJT-UHFFFAOYSA-N
SMILES :C(NC1=CC=C(C(N2C3=CC=C(Cl)C=C3C(O)CCC2)=O)C(C)=C1)(=O)C1=CC=CC=C1C

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Tolvaptan(trade names Samsca and Jinarc) is an oral selective vasopressin antagonist developed by Otsuka for the treatment of hyponatremia, and it is a non-peptide selective antidiuretic hormone receptor antagonist. The drug can increase the concentration of sodium ions in the plasma, and help the excess water discharge from the urine. The drug could enhance the ability of the kidney to deal with water, and significantly reduce the weight and edema of patients while not accompanied by increased electrolyte excretion, without destroying the blood electrolyte balance. The drug can be used to treat hyponatremia caused by congestive heart failure, various edematous diseases, cirrhosis and antidiuretic hormone deficiency syndrome. The study found that, when the plasma sodium concentration decreased, in order to maintain the balance of sodium concentration inside and outside the cell, extracellular fluid will enter the cell, so the cells will swell. When the brain cells swell, it will lead to a variety of hyponatremia symptoms, including dizziness, weakness, headache, nausea, confusion, consciousness and convulsions. Severe hyponatremia can lead to coma and death. There is no corresponding study of tolvaptan tablets in patients with severe hyponatremia.

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