SU 9516
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- $29 - $1800
- Product name: SU 9516
- CAS: 377090-84-1
- MF: C13H11N3O2
- MW: 241.25
- EINECS:
- MDL Number:MFCD05865243
- Synonyms:(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one;(Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one;(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one SU9516;(3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one;3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one;CS-1784;3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one;SU 9516;SU-9516
28 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- ManufacturerAK Scientific
- Product number2734AH
- Product description3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
- Packaging1mg
- Price$92
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2734AH
- Product description3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
- Packaging5mg
- Price$159
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2734AH
- Product description3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
- Packaging25mg
- Price$386
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA269439
- Product descriptionSU9516 98+%
- Packaging1mg
- Price$29
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA269439
- Product descriptionSU9516 98+%
- Packaging5mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA269439
- Product descriptionSU9516 98+%
- Packaging10mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA269439
- Product descriptionSU9516 98+%
- Packaging25mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA269439
- Product descriptionSU9516 98+%
- Packaging50mg
- Price$128
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA269439
- Product descriptionSU9516 98+%
- Packaging100mg
- Price$167
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA269439
- Product descriptionSU9516 98+%
- Packaging250mg
- Price$333
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA269439
- Product descriptionSU9516 98+%
- Packaging1g
- Price$832
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4467
- Product descriptionSU9516
- Packaging10mg
- Price$173
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4467
- Product descriptionSU9516
- Packaging50mg
- Price$677
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14796
- Product descriptionSU 9516 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14796
- Product descriptionSU 9516 ≥98%
- Packaging5mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14796
- Product descriptionSU 9516 ≥98%
- Packaging10mg
- Price$139
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2734AH | 3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one | 1mg | $92 | 2021-12-16 | Buy |
| AK Scientific | 2734AH | 3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one | 5mg | $159 | 2021-12-16 | Buy |
| AK Scientific | 2734AH | 3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one | 25mg | $386 | 2021-12-16 | Buy |
| Ambeed | A269439 | SU9516 98+% | 1mg | $29 | 2021-12-16 | Buy |
| Ambeed | A269439 | SU9516 98+% | 5mg | $58 | 2021-12-16 | Buy |
| Ambeed | A269439 | SU9516 98+% | 10mg | $75 | 2021-12-16 | Buy |
| Ambeed | A269439 | SU9516 98+% | 25mg | $98 | 2021-12-16 | Buy |
| Ambeed | A269439 | SU9516 98+% | 50mg | $128 | 2021-12-16 | Buy |
| Ambeed | A269439 | SU9516 98+% | 100mg | $167 | 2021-12-16 | Buy |
| Ambeed | A269439 | SU9516 98+% | 250mg | $333 | 2021-12-16 | Buy |
| Ambeed | A269439 | SU9516 98+% | 1g | $832 | 2021-12-16 | Buy |
| ApexBio Technology | A4467 | SU9516 | 10mg | $173 | 2021-12-16 | Buy |
| ApexBio Technology | A4467 | SU9516 | 50mg | $677 | 2021-12-16 | Buy |
| Cayman Chemical | 14796 | SU 9516 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 14796 | SU 9516 ≥98% | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 14796 | SU 9516 ≥98% | 10mg | $139 | 2024-03-01 | Buy |
Properties
storage temp. :Store at +4°C
solubility :DMSO: ~17 mg/mL
form :crystalline
color :brown
solubility :DMSO: ~17 mg/mL
form :crystalline
color :brown
Safety Information
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Description
SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1). It does not inhibit PKC, p38, PDGFR, or EGFR (IC50’s = >10 μM). SU 9516 inhibits phosphorylation of the retinoblastoma protein pRb, resulting in increased pRb/E2F complex formation, cell-cycle arrest, and subsequent apoptosis. In leukemia cells (U937, Jurkat, and HL-60 cells) SU 9516 downregulates transcription of the antiapoptotic protein Mcl-1, leading to mitochondrial injury and cell death.Related product price
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