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ChemicalBook >> CAS DataBase List >> PHA-793887

PHA-793887

PHA-793887 price.
  • $43 - $9556.47
  • Product name: PHA-793887
  • CAS: 718630-59-2
  • MF: C19H31N5O2
  • MW: 361.48
  • EINECS:
  • MDL Number:MFCD17169992
  • Synonyms:3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide;PHA-793887;N-(6,6-dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide;3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide PHA-793887;PHA-793887 3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide;PHA-793887;PHA793887;3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c];PHA-793887 USP/EP/BP
27 prices
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 1MG
  • 5MG
  • 10mg
  • 25mg
  • 50MG
  • 100mg
  • 250mg
  • 1G
  • ManufacturerAK Scientific
  • Product numberX7380
  • Product descriptionPHA-793887
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000927
  • Product descriptionN-(6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1H,4H,5H,6H-PYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE 95.00%
  • Packaging1MG
  • Price$148.05
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000927
  • Product descriptionN-(6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1H,4H,5H,6H-PYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE 95.00%
  • Packaging5MG
  • Price$927.47
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000927
  • Product descriptionN-(6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1H,4H,5H,6H-PYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE 95.00%
  • Packaging10MG
  • Price$1127.86
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000927
  • Product descriptionN-(6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1H,4H,5H,6H-PYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE 95.00%
  • Packaging50MG
  • Price$2946.98
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000927
  • Product descriptionN-(6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1H,4H,5H,6H-PYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE 95.00%
  • Packaging1G
  • Price$9556.47
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5459
  • Product descriptionPHA-793887
  • Packaging25mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180756
  • Product descriptionPHA-793887 >99%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180756
  • Product descriptionPHA-793887 >99%
  • Packaging250mg
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180756
  • Product descriptionPHA-793887 >99%
  • Packaging1g
  • Price$2245.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFM145343
  • Product descriptionPHA 793887
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFM145343
  • Product descriptionPHA 793887
  • Packaging50mg
  • Price$612.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18388
  • Product descriptionPHA-793887 ≥95%
  • Packaging1mg
  • Price$43
  • Updated2023-06-20
  • Buy
  • ManufacturerCayman Chemical
  • Product number18388
  • Product descriptionPHA-793887 ≥95%
  • Packaging5mg
  • Price$46
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18388
  • Product descriptionPHA-793887 ≥95%
  • Packaging10mg
  • Price$88
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18388
  • Product descriptionPHA-793887 ≥95%
  • Packaging50mg
  • Price$230
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7380 PHA-793887 10mg $180 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000927 N-(6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1H,4H,5H,6H-PYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE 95.00% 1MG $148.05 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000927 N-(6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1H,4H,5H,6H-PYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE 95.00% 5MG $927.47 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000927 N-(6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1H,4H,5H,6H-PYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE 95.00% 10MG $1127.86 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000927 N-(6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1H,4H,5H,6H-PYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE 95.00% 50MG $2946.98 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000927 N-(6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1H,4H,5H,6H-PYRROLO[3,4-C]PYRAZOL-3-YL)-3-METHYLBUTANAMIDE 95.00% 1G $9556.47 2021-12-16 Buy
ApexBio Technology A5459 PHA-793887 25mg $300 2021-12-16 Buy
Biorbyt Ltd orb180756 PHA-793887 >99% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb180756 PHA-793887 >99% 250mg $1133.9 2021-12-16 Buy
Biorbyt Ltd orb180756 PHA-793887 >99% 1g $2245.7 2021-12-16 Buy
Biosynth Carbosynth FM145343 PHA 793887 10mg $175 2021-12-16 Buy
Biosynth Carbosynth FM145343 PHA 793887 50mg $612.5 2021-12-16 Buy
Cayman Chemical 18388 PHA-793887 ≥95% 1mg $43 2023-06-20 Buy
Cayman Chemical 18388 PHA-793887 ≥95% 5mg $46 2024-03-01 Buy
Cayman Chemical 18388 PHA-793887 ≥95% 10mg $88 2024-03-01 Buy
Cayman Chemical 18388 PHA-793887 ≥95% 50mg $230 2024-03-01 Buy

Properties

Melting point :>147°C (dec.)
Boiling point :596.2±50.0 °C(Predicted)
Density :1.176±0.06 g/cm3(Predicted)
storage temp. :Hygroscopic, Refrigerator, under inert atmosphere
solubility :DMSO (Slightly), Methanol(Slightly)
pka :13.74±0.40(Predicted)
form :Solid
color :Off-White to Pale Yellow
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

PHA-793887 is a pyrrolo[3,4-c]pyrazole that inhibits cyclin-dependent kinases Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk7/cyclin H with IC50 values of 8, 8, 5, and 10 nM, respectively. It is more than 6-fold selective for these kinases over Cdk1/cyclin B, Cdk4/cyclin D1, Cdk9/cyclin T, and GSK3β (IC50s = 60, 62, 138, and 79 nM, respectively). PHA-793887 is cytotoxic to human ovarian A2780, colon HCT-116, pancreatic BX-PC3, and leukemic K562, KU812, KCL22, and TOM1 cells both in vitro and in xenograft models. This compound has been examined in patients with solid tumors in phase 1 clinical trials.

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