IWR-1-endo
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- $60 - $1802
- Product name: IWR-1-endo
- CAS: 1127442-82-3
- MF: C25H19N3O3
- MW: 409.44
- EINECS:
- MDL Number:MFCD18086875
- Synonyms:[(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide;Benzamide, 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-, rel-;endo-IWR 1;IWR-1-endo;rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-Methano-2H-isoindol-2-yl]-N-8-quinolinylbenzaMide;rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo;IWR-1-endo, >=98%;ENDO-IWR 1;IWR-1-ENDO;IWR1;IWR 1
34 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 50
- 5mg
- 10
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 1000mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3581-M025
- Product descriptionIWR-1-endo ≥98%
- Packaging25mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1806AH
- Product descriptionIWR-1-endo
- Packaging5mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1806AH
- Product descriptionIWR-1-endo
- Packaging10mg
- Price$162
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA205590
- Product descriptionrel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+%
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA205590
- Product descriptionrel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+%
- Packaging10mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA205590
- Product descriptionrel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+%
- Packaging50mg
- Price$311
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000752
- Product descriptionIWR-1-ENDO 95.00%
- Packaging10MG
- Price$930.3
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000752
- Product descriptionIWR-1-ENDO 95.00%
- Packaging100MG
- Price$1732.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2306
- Product descriptionIWR-1-endo
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60085
- Product descriptionIWR-1-endo ≥98%
- Packaging10mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2510
- Product descriptionIWR-1-endo-IWR-1|endo-IWR-1 99%
- Packaging10mg
- Price$93.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180916
- Product descriptionIWR-1 >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180916
- Product descriptionIWR-1 >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180916
- Product descriptionIWR-1 >98%
- Packaging1000mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFI24746
- Product descriptionendo-IWR 1
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFI24746
- Product descriptionendo-IWR 1
- Packaging50mg
- Price$275
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3581-M025 | IWR-1-endo ≥98% | 25mg | $360 | 2021-12-16 | Buy |
| AK Scientific | 1806AH | IWR-1-endo | 5mg | $118 | 2021-12-16 | Buy |
| AK Scientific | 1806AH | IWR-1-endo | 10mg | $162 | 2021-12-16 | Buy |
| Ambeed | A205590 | rel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+% | 5mg | $72 | 2021-12-16 | Buy |
| Ambeed | A205590 | rel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+% | 10mg | $122 | 2021-12-16 | Buy |
| Ambeed | A205590 | rel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+% | 50mg | $311 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000752 | IWR-1-ENDO 95.00% | 10MG | $930.3 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000752 | IWR-1-ENDO 95.00% | 100MG | $1732.5 | 2021-12-16 | Buy |
| ApexBio Technology | B2306 | IWR-1-endo | 10mg | $70 | 2021-12-16 | Buy |
| Arctom | CFN60085 | IWR-1-endo ≥98% | 10mg | $168 | 2021-12-16 | Buy |
| Axon Medchem | Axon2510 | IWR-1-endo-IWR-1|endo-IWR-1 99% | 10mg | $93.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180916 | IWR-1 >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180916 | IWR-1 >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180916 | IWR-1 >98% | 1000mg | $1802 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI24746 | endo-IWR 1 | 10mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI24746 | endo-IWR 1 | 50mg | $275 | 2021-12-16 | Buy |
Properties
alpha :-3.0～+3.0°(20℃/D)(c=0.1,CH3CN)
Boiling point :643.9±55.0 °C(Predicted)
Density :1.425±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
pka :11.88±0.43(Predicted)
form :Liquid
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :643.9±55.0 °C(Predicted)
Density :1.425±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
pka :11.88±0.43(Predicted)
form :Liquid
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. It inhibits, at 10 μM, Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, Ck1, and GSK3β. IWR-1-endo stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK3β. The IWR compound does not change the de novo synthesis of Axin2, alter the affinity of Axin2 for β-catenin, or inhibit the proteasome. It has a half-life of 60 minutes in murine whole blood and 20 minutes in intact murine hepatocytes. In in vivo tests, IWR-1-endo inhibits zebrafish tail fin regeneration with a minimum inhibitory concentration of 0.5 μM. The IWR-1-exo diastereomer exhibits much less activity against the Wnt/β-catenin pathway and has been used as a control.More related product prices
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