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ChemicalBook >> CAS DataBase List >> Gefitinib

Gefitinib

Gefitinib price.
  • $5 - $1141
  • Product name: Gefitinib
  • CAS: 184475-35-2
  • MF: C22H24ClFN4O3
  • MW: 446.9
  • EINECS:643-034-7
  • MDL Number:MFCD04307832
  • Synonyms:N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine Gefitinib;Gefitinib, >=99%;GEFITINIB RELATED COMPOUND;Gefitinib N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;GEFITINIB;n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;ZD 1839;4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
66 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
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  • Arctom
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  • Cayman Chemical
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  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
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Package
  • Y0001813
  • 10mM(in 1mL DMSO)
  • 1unit
  • 5mg
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  • 100 mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1042-M005
  • Product descriptionGefitinib ≥95%
  • Packaging5mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH018
  • Product descriptionGefitinib
  • Packaging1g
  • Price$21
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ94474
  • Product descriptionGefitinib
  • Packaging5g
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH018
  • Product descriptionGefitinib
  • Packaging10g
  • Price$87
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH018
  • Product descriptionGefitinib
  • Packaging100g
  • Price$427
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109874
  • Product descriptionN-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+%
  • Packaging100mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109874
  • Product descriptionN-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+%
  • Packaging250mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109874
  • Product descriptionN-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+%
  • Packaging1g
  • Price$13
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109874
  • Product descriptionN-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+%
  • Packaging5g
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109874
  • Product descriptionN-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+%
  • Packaging10g
  • Price$76
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109874
  • Product descriptionN-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+%
  • Packaging25g
  • Price$153
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA109874
  • Product descriptionN-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+%
  • Packaging100g
  • Price$522
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8219
  • Product descriptionGefitinib(ZD1839)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8219
  • Product descriptionGefitinib(ZD1839)
  • Packaging100mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8219
  • Product descriptionGefitinib(ZD1839)
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8219
  • Product descriptionGefitinib(ZD1839)
  • Packaging250mg
  • Price$70
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1042-M005 Gefitinib ≥95% 5mg $59 2021-12-16 Buy
AK Scientific H018 Gefitinib 1g $21 2021-12-16 Buy
AK Scientific J94474 Gefitinib 5g $45 2021-12-16 Buy
AK Scientific H018 Gefitinib 10g $87 2021-12-16 Buy
AK Scientific H018 Gefitinib 100g $427 2021-12-16 Buy
Ambeed A109874 N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+% 100mg $5 2021-12-16 Buy
Ambeed A109874 N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+% 250mg $6 2021-12-16 Buy
Ambeed A109874 N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+% 1g $13 2021-12-16 Buy
Ambeed A109874 N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+% 5g $41 2021-12-16 Buy
Ambeed A109874 N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+% 10g $76 2021-12-16 Buy
Ambeed A109874 N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+% 25g $153 2021-12-16 Buy
Ambeed A109874 N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine 98+% 100g $522 2021-12-16 Buy
ApexBio Technology A8219 Gefitinib(ZD1839) 1unit $28 2021-12-16 Buy
ApexBio Technology A8219 Gefitinib(ZD1839) 100mg $55 2021-12-16 Buy
ApexBio Technology A8219 Gefitinib(ZD1839) 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A8219 Gefitinib(ZD1839) 250mg $70 2021-12-16 Buy

Properties

Melting point :119-1200C
Boiling point :586.8±50.0 °C(Predicted)
Density :1.322±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml).
pka :7.00±0.10(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
CAS DataBase Reference :184475-35-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Overactivity of the epidermal growth factor receptor-associated tyrosine kinase (EGFR-TK) has been associated with a number of cancers and thus TK inhibitors could be potential therapeutic agents to prevent malignant growth. Gefitinib is a selective EGFR-TK inhibitor that blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50s ranging between 0.2-0.4 μM. By interfering with the intracellular kinase domain, gefitinib prevents EGFR autophosphorylation and prevents downstream signal transduction. Gefitinib has been used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval for this compound (Iressa?) when a phase III trial failed to demonstrate an overall survival benefit. Gefitinib appears to be most efficacious in treating certain EGFR gene mutations that are prevalent in Asian populations.

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