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ChemicalBook >> CAS DataBase List >> GO 6976

GO 6976

GO 6976 price.
  • $49 - $2500
  • Product name: GO 6976
  • CAS: 136194-77-9
  • MF: C24H18N4O
  • MW: 378.43
  • EINECS:200-258-5
  • MDL Number:MFCD00236434
  • Synonyms:InSolution? G? 6976 ;5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile;Go6976,5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile;PD406976;12-(2-CYANOETHYL)-6,7,12,13-TETRAHYDRO-13-METHYL-5-OXO-5H-INDOLO(2,3-A)PYRROLO(3,4-C)-CARBAZOLE;12-2(2-CYANOETHYL)-6,7,12,13-TETRAHYDRO-13-METHYL-5-OXO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE;GO 6976;G6976
24 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 500μg
  • 1mg
  • 2mg
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 500U
  • 1g
  • 1ml
  • ManufacturerAK Scientific
  • Product numberSYN5462
  • Product descriptionGo6976
  • Packaging50mg
  • Price$1880
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8341
  • Product descriptionGo6976
  • Packaging5mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8341
  • Product descriptionGo6976
  • Packaging25mg
  • Price$441
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60288
  • Product descriptionGo6976
  • Packaging5mg
  • Price$338
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG168444
  • Product descriptionGo 6976
  • Packaging25mg
  • Price$1750
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG168444
  • Product descriptionGo 6976
  • Packaging10mg
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG168444
  • Product descriptionGo 6976
  • Packaging5mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG168444
  • Product descriptionGo 6976
  • Packaging2mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG168444
  • Product descriptionGo 6976
  • Packaging1mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13310
  • Product descriptionG? 6976 ≥98%
  • Packaging500μg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13310
  • Product descriptionG? 6976 ≥98%
  • Packaging1mg
  • Price$92
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13310
  • Product descriptionG? 6976 ≥98%
  • Packaging5mg
  • Price$216
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0002498
  • Product descriptionGo6976 99.34%
  • Packaging1mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0002498
  • Product descriptionGo6976 99.34%
  • Packaging5mg
  • Price$600
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN16571
  • Product descriptionGo6976
  • Packaging5mg
  • Price$124
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN16571
  • Product descriptionGo6976
  • Packaging10mg
  • Price$199
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5462 Go6976 50mg $1880 2021-12-16 Buy
ApexBio Technology A8341 Go6976 5mg $147 2021-12-16 Buy
ApexBio Technology A8341 Go6976 25mg $441 2021-12-16 Buy
Arctom CFN60288 Go6976 5mg $338 2021-12-16 Buy
Biosynth Carbosynth BG168444 Go 6976 25mg $1750 2021-12-16 Buy
Biosynth Carbosynth BG168444 Go 6976 10mg $800 2021-12-16 Buy
Biosynth Carbosynth BG168444 Go 6976 5mg $450 2021-12-16 Buy
Biosynth Carbosynth BG168444 Go 6976 2mg $280 2021-12-16 Buy
Biosynth Carbosynth BG168444 Go 6976 1mg $150 2021-12-16 Buy
Cayman Chemical 13310 G? 6976 ≥98% 500μg $49 2024-03-01 Buy
Cayman Chemical 13310 G? 6976 ≥98% 1mg $92 2024-03-01 Buy
Cayman Chemical 13310 G? 6976 ≥98% 5mg $216 2024-03-01 Buy
ChemScene CS-0002498 Go6976 99.34% 1mg $200 2021-12-16 Buy
ChemScene CS-0002498 Go6976 99.34% 5mg $600 2021-12-16 Buy
CSNpharm CSN16571 Go6976 5mg $124 2021-12-16 Buy
CSNpharm CSN16571 Go6976 10mg $199 2021-12-16 Buy

Properties

Melting point :>221°C (dec.)
Boiling point :652.3±55.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Acetonitrile (Very Slightly, Heated), DMSO (Slightly), Methanol (Very Slightly)
form :Off-white solid
pka :14.39±0.20(Predicted)
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

G? 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively. It does not inhibit the activity of PKCδ, PKCε, or PKCζ (IC50s > 3 μM), indicating a preference for the Ca2+-dependent subtypes, PKCα and PKCβ1. G? 6976 also inhibits the checkpoint kinases Chk1/2. It was shown to abrogate DNA damage-induced S- and G2-phase cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.

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