GDC-0068
- $28 - $2864
- Product name: GDC-0068
- CAS: 1001264-89-6
- MF: C24H32ClN5O2
- MW: 458
- EINECS:
- MDL Number:MFCD22124514
- Synonyms:(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone;Ipatasertib (GDC-0068);(S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one;(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone Ipatasertib (GDC-0068);GDC-0068 (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone;(2S)-2-(4-Chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-1-piperazinyl}-3-(isopropylamino)-1-propanone;Ipatasertib (GDC-0068,RG 7440);GDC-0068;RG7440; GDC0068; GDC 0068; RG-7440; RG 7440
37 prices
Selected condition:
Brand
- AK Scientific
- Alfa Aesar
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1mg
- 1unit
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 10mM(in 1mL DMSO)
- 250mg
- 500mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5726
- Product descriptionGDC-0068
- Packaging50mg
- Price$757
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ67082
- Product descriptionGDC-0068, 98%
- Packaging5mg
- Price$241
- Updated2023-06-20
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013721
- Product descriptionGDC-0068 95.00%
- Packaging5MG
- Price$459.8
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3006
- Product descriptionGDC-0068(RG7440)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3006
- Product descriptionGDC-0068(RG7440)
- Packaging5mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3006
- Product descriptionGDC-0068(RG7440)
- Packaging10mM(in 1mL DMSO)
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3006
- Product descriptionGDC-0068(RG7440)
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3006
- Product descriptionGDC-0068(RG7440)
- Packaging50mg
- Price$520
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3006
- Product descriptionGDC-0068(RG7440)
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60068
- Product descriptionIpatasertib(GDC-0068) ≥98%
- Packaging10mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146127
- Product descriptionIpatasertib (GDC-0068) >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146127
- Product descriptionIpatasertib (GDC-0068) >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146127
- Product descriptionIpatasertib (GDC-0068) >98%
- Packaging1g
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC43222
- Product descriptionIpatasertib
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC43222
- Product descriptionIpatasertib
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC43222
- Product descriptionIpatasertib
- Packaging25mg
- Price$187.5
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | SYN5726 | GDC-0068 | 50mg | $757 | 2021-12-16 | Buy |
Alfa Aesar | J67082 | GDC-0068, 98% | 5mg | $241 | 2023-06-20 | Buy |
American Custom Chemicals Corporation | API0013721 | GDC-0068 95.00% | 5MG | $459.8 | 2021-12-16 | Buy |
ApexBio Technology | A3006 | GDC-0068(RG7440) | 1unit | $28 | 2021-12-16 | Buy |
ApexBio Technology | A3006 | GDC-0068(RG7440) | 5mg | $100 | 2021-12-16 | Buy |
ApexBio Technology | A3006 | GDC-0068(RG7440) | 10mM(in 1mL DMSO) | $100 | 2021-12-16 | Buy |
ApexBio Technology | A3006 | GDC-0068(RG7440) | 10mg | $150 | 2021-12-16 | Buy |
ApexBio Technology | A3006 | GDC-0068(RG7440) | 50mg | $520 | 2021-12-16 | Buy |
ApexBio Technology | A3006 | GDC-0068(RG7440) | 100mg | $650 | 2021-12-16 | Buy |
Arctom | CFN60068 | Ipatasertib(GDC-0068) ≥98% | 10mg | $208 | 2021-12-16 | Buy |
Biorbyt Ltd | orb146127 | Ipatasertib (GDC-0068) >98% | 100mg | $690.2 | 2021-12-16 | Buy |
Biorbyt Ltd | orb146127 | Ipatasertib (GDC-0068) >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
Biorbyt Ltd | orb146127 | Ipatasertib (GDC-0068) >98% | 1g | $2691.1 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC43222 | Ipatasertib | 5mg | $60 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC43222 | Ipatasertib | 10mg | $100 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC43222 | Ipatasertib | 25mg | $187.5 | 2021-12-16 | Buy |
Properties
Melting point :>106°C (dec.)
Boiling point :669.4±55.0 °C(Predicted)
Density :1.254
storage temp. :Hygroscopic, Refrigerator, under inert atmosphere
solubility :Soluble in DMSO.
pka :13.11±0.40(Predicted)
form :Solid
color :peachy
Boiling point :669.4±55.0 °C(Predicted)
Density :1.254
storage temp. :Hygroscopic, Refrigerator, under inert atmosphere
solubility :Soluble in DMSO.
pka :13.11±0.40(Predicted)
form :Solid
color :peachy
Safety Information
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Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays. It is 620-fold selective for Akt over protein kinase A and has been shown to block Akt signaling selectively in cultured tumor cell lines characterized by activated Akt, halting cell cycle progression and reducing cell viability. In multiple tumor xenograft models, oral administration of GDC-0068 at 100 mg/kg/day can lead to delayed tumor growth and regression.More related product prices
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