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ChemicalBook >> CAS DataBase List >> Epothilone A

Epothilone A

Epothilone A price.
  • $44 - $4469.3
  • Product name: Epothilone A
  • CAS: 152044-53-6
  • MF: C26H39NO6S
  • MW: 493.66
  • EINECS:
  • MDL Number:MFCD26960884
  • Synonyms:4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-;Epothilone-S;(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;Epothile;4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetraMethyl-3- [(1E)-1-Methy;Ixabepilone Impurity 5 (Epothilone A);(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione;(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone A
29 prices
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Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 10μg
  • 10mg
  • 25mg
  • 250mg
  • 1g
  • 1000mg
  • 10mM(in 1mL DMSO)
  • 0.1MG
  • 100ug
  • 1MG
  • 5mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product numberX7523
  • Product descriptionEpothiloneA
  • Packaging10mg
  • Price$336
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA408460
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione 98%
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA408460
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione 98%
  • Packaging10mg
  • Price$155
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA408460
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione 98%
  • Packaging50mg
  • Price$306
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA408460
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione 98%
  • Packaging100mg
  • Price$457
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000872
  • Product descriptionEPOTHILONE A 95.00%
  • Packaging0.1MG
  • Price$742.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000872
  • Product descriptionEPOTHILONE A 95.00%
  • Packaging1MG
  • Price$2194.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1623
  • Product descriptionEpothiloneA
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1623
  • Product descriptionEpothiloneA
  • Packaging10mM(in 1mL DMSO)
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1623
  • Product descriptionEpothiloneA
  • Packaging25mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1623
  • Product descriptionEpothiloneA
  • Packaging100mg
  • Price$980
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180980
  • Product descriptionEpothilone A >98%
  • Packaging100mg
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180980
  • Product descriptionEpothilone A >98%
  • Packaging250mg
  • Price$2245.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180980
  • Product descriptionEpothilone A >98%
  • Packaging1000mg
  • Price$4469.3
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16482
  • Product descriptionEpothilone A ≥95%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16482
  • Product descriptionEpothilone A ≥95%
  • Packaging5mg
  • Price$118
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7523 EpothiloneA 10mg $336 2021-12-16 Buy
Ambeed A408460 (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione 98% 5mg $120 2021-12-16 Buy
Ambeed A408460 (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione 98% 10mg $155 2021-12-16 Buy
Ambeed A408460 (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione 98% 50mg $306 2021-12-16 Buy
Ambeed A408460 (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione 98% 100mg $457 2021-12-16 Buy
American Custom Chemicals Corporation INB0000872 EPOTHILONE A 95.00% 0.1MG $742.5 2021-12-16 Buy
American Custom Chemicals Corporation INB0000872 EPOTHILONE A 95.00% 1MG $2194.5 2021-12-16 Buy
ApexBio Technology A1623 EpothiloneA 5mg $90 2021-12-16 Buy
ApexBio Technology A1623 EpothiloneA 10mM(in 1mL DMSO) $160 2021-12-16 Buy
ApexBio Technology A1623 EpothiloneA 25mg $360 2021-12-16 Buy
ApexBio Technology A1623 EpothiloneA 100mg $980 2021-12-16 Buy
Biorbyt Ltd orb180980 Epothilone A >98% 100mg $1133.9 2021-12-16 Buy
Biorbyt Ltd orb180980 Epothilone A >98% 250mg $2245.7 2021-12-16 Buy
Biorbyt Ltd orb180980 Epothilone A >98% 1000mg $4469.3 2021-12-16 Buy
Cayman Chemical 16482 Epothilone A ≥95% 1mg $44 2024-03-01 Buy
Cayman Chemical 16482 Epothilone A ≥95% 5mg $118 2024-03-01 Buy

Properties

Melting point :95℃
alpha :D21 -47.1° (c = 1.0 in methanol)
Boiling point :683.3±55.0 °C(Predicted)
Density :1.143
storage temp. :-20°C
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
pka :13.57±0.70(Predicted)
form :solid
color :White to Off-White
Stability :Stable under recommended storage conditions., Stable Under Recommended Storage C
InChIKey :HESCAJZNRMSMJG-KKQRBIROSA-N
SMILES :[C@]12([H])[C@]([H])(O1)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(/C)=C/C1=CSC(C)=N1)C2

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Epothilone A (Epo A) is a biologically active macrolide produced from the fermentation of the soil bacteria S. cellulosum that was discovered as a potent antimicrotubule agent. In competition assays, epo A binds to β-tubulin with a similar order of magnitude as the binding of paclitaxel to β-tubulin (IC50s = 2.3 and 3.6 μM, respectively). Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 μM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B .

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