Epothilone A
Epothilone A (Epo A) is a naturally occurring microtubule-stabilizing macrolide that was first isolated from the myxobacterium?Sorangium cellulosum. The IC50 value of Epothilone A in HCT-116 cell line is?4.4 nM [1].
It has been found that the SKOV-3 human ovarian cancer cells were susceptible to Epothilone A with IC50 value of 20.4?±?1.4 nM [2]. The antiproliferative capacity of Epothilone A in SKOV-3 cell line (measured as IC50?after 72?h continuous treatment) was six times greater than that of PTX’s. Besides, Epothilone A induced time coursedependent apoptosis and necrosis [2].?
References:
[1] Regueiro-Ren A1,?Borzilleri RM,?Zheng X,?Kim SH,?Johnson JA,?Fairchild CR,?Lee FY,?Long BH,?Vite GD. Synthesis?and?biological?activity?of?novel?epothilone?aziridines. Org Lett.?2001 Aug 23;3(17):2693-6.
[2] Rogalska A1,?Marczak A,?Gajek A,?Szwed M,??liwińska A,?Drzewoski J,?Jó?wiak Z. Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B. Toxicol In Vitro.?2013 Feb;27(1):239-49.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 493.66 |
| Cas No. | 152044-53-6 |
| Formula | C26H39NO6S |
| Solubility | insoluble in H2O; ≥17.45 mg/mL in DMSO; ≥43.2 mg/mL in EtOH |
| Chemical Name | (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione |
| SDF | Download SDF |
| Canonical SMILES | CC1CCCC2C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | Epothilone A is a macrolide antitumor agent with microtubule-stabilizing activity. | |||||
| Targets | MDR CCRF-CEM/VBL100 cells | |||||
| IC50 | 20 nM | |||||
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
Related Biological Data
