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ChemicalBook >> CAS DataBase List >> ABT-199

ABT-199

ABT-199 price.
  • $12 - $4766.8
  • Product name: ABT-199
  • CAS: 1257044-40-8
  • MF: C45H50ClN7O7S
  • MW: 868.44
  • EINECS:820-130-9
  • MDL Number:MFCD23160052
  • Synonyms:ABT-199;ABT-199 (GDC-0199);GDC-0199;ABT-199 100MG;2-(1H-Pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)met;ABT-199, Venetoclax;GDC 0199;GDC0199;Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-
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Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
Package
  • 20mg
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  • 50 mg
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  • 10mM(in 1mL DMSO)
  • 1mg
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  • 100mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product numberSYN5490
  • Product descriptionABT-199
  • Packaging10mg
  • Price$113
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX3609
  • Product descriptionVenetoclax
  • Packaging100mg
  • Price$1667
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156386
  • Product description2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+%
  • Packaging1mg
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156386
  • Product description2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+%
  • Packaging2mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156386
  • Product description2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+%
  • Packaging5mg
  • Price$19
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156386
  • Product description2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+%
  • Packaging10mg
  • Price$23
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156386
  • Product description2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+%
  • Packaging250mg
  • Price$48
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156386
  • Product description2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+%
  • Packaging1g
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA156386
  • Product description2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+%
  • Packaging5g
  • Price$302
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8194
  • Product descriptionABT-199
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8194
  • Product descriptionABT-199
  • Packaging1mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8194
  • Product descriptionABT-199
  • Packaging5mg
  • Price$126
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8194
  • Product descriptionABT-199
  • Packaging10mM(in 1mL DMSO)
  • Price$153
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8194
  • Product descriptionABT-199
  • Packaging50mg
  • Price$456
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60007
  • Product descriptionVenetoclax(ABT-199) ≥98%
  • Packaging20mg
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146094
  • Product descriptionVenetoclax (ABT-199) >99%
  • Packaging1g
  • Price$1208.7
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5490 ABT-199 10mg $113 2021-12-16 Buy
AK Scientific X3609 Venetoclax 100mg $1667 2021-12-16 Buy
Ambeed A156386 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+% 1mg $12 2021-12-16 Buy
Ambeed A156386 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+% 2mg $15 2021-12-16 Buy
Ambeed A156386 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+% 5mg $19 2021-12-16 Buy
Ambeed A156386 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+% 10mg $23 2021-12-16 Buy
Ambeed A156386 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+% 250mg $48 2021-12-16 Buy
Ambeed A156386 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+% 1g $96 2021-12-16 Buy
Ambeed A156386 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 99+% 5g $302 2021-12-16 Buy
ApexBio Technology A8194 ABT-199 1unit $28 2021-12-16 Buy
ApexBio Technology A8194 ABT-199 1mg $42 2021-12-16 Buy
ApexBio Technology A8194 ABT-199 5mg $126 2021-12-16 Buy
ApexBio Technology A8194 ABT-199 10mM(in 1mL DMSO) $153 2021-12-16 Buy
ApexBio Technology A8194 ABT-199 50mg $456 2021-12-16 Buy
Arctom CFN60007 Venetoclax(ABT-199) ≥98% 20mg $188 2021-12-16 Buy
Biorbyt Ltd orb146094 Venetoclax (ABT-199) >99% 1g $1208.7 2021-12-16 Buy

Properties

Melting point :>150°C (dec.)
Density :1.340±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly)
form :Yellow solid.
pka :4.09±0.10(Predicted)
color :Light Yellow to Yellow
InChIKey :LQBVNQSMGBZMKD-UHFFFAOYSA-N
SMILES :C(NS(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)(=O)=O)(=O)C1=CC=C(N2CCN(CC3CCC(C)(C)CC=3C3=CC=C(Cl)C=C3)CC2)C=C1OC1=CN=C2NC=CC2=C1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

ABT-199, also known as venetoclax, is a small, oral chemical molecule used for the treatment of chronic lymphocytic leukemia (CLL) associated with a specific chromosomal abnormality. As a second line treatment drug of CLL, ABT-199 take effects through acting as a BH3-mimetic and inhibitor of Bcl-2 (the anti-apoptotic B-cell lymphoma-2protein), further inducing apoptosis of CLL cells but not platelets. It also has the potential for the treatment of ER-positive breast cancer.

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